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在一名2.5个月大患有半球型斯特奇-韦伯综合征并反复癫痫持续状态的婴儿中,使用神经导航和增强现实支持进行微创垂直半球切除术。

Minimal invasive vertical hemispherotomy in a 2.5-month-old infant with hemispheric Sturge-Weber Syndrome and recurrent status epilepticus using neuronavigation and augmented reality support.

作者信息

Roessler Karl, Weiss Jonathan, Shawarba Julia, Quinot Valerie, Kasprian Gregor, Niederle Martin, Czech Thomas, Mayer Florian, Dorfer Christian, Feucht Martha

机构信息

Neurosurgical Department, Medical University of Vienna, 1090, Vienna, Austria.

Comprehensive Center of Clinical Neurosciences and Mental Health (C3 N-MH), Medical University of Vienna, 1090, Vienna, Austria.

出版信息

Childs Nerv Syst. 2025 May 30;41(1):195. doi: 10.1007/s00381-025-06857-7.

DOI:10.1007/s00381-025-06857-7
PMID:40447874
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12125049/
Abstract

Hemispherotomy in infants under the age of 3 months is considered a high-risk procedure and is not routinely performed. A 2.5-month-old female infant weighing 5.1 kg successfully underwent a right vertical hemispherotomy after developing status epilepticus due to a right hemispheric Sturge-Weber meningo-angiomatosis. The surgical technique involved skull fixation at the skull base using kid pins to facilitate image-guided surgery with neuronavigation and augmented reality within the eyepiece of the microscope employing the vertical hemispherotomy technique. The surgical course was uneventful, with moderate blood loss (100 mL of red blood cells, 90 mL of fresh frozen plasma, and 150 mg of tranexamic acid transfused). The surgery duration was within 2 h. Postoperatively, seizures ceased immediately, and the infant experienced rapid developmental and neurological progress, remaining seizure-free for 8 months after surgery (Engel 1a) now.

摘要

3个月以下婴儿的大脑半球切除术被认为是一种高风险手术,通常不会进行。一名体重5.1千克、2.5个月大的女婴因右侧大脑半球斯特奇-韦伯综合征脑膜血管瘤病发生癫痫持续状态后,成功接受了右侧垂直大脑半球切除术。手术技术包括在颅底使用儿童针进行颅骨固定,以便在显微镜目镜内通过神经导航和增强现实技术进行图像引导手术,并采用垂直大脑半球切除术技术。手术过程顺利,术中失血适中(输注了100毫升红细胞、90毫升新鲜冰冻血浆和150毫克氨甲环酸)。手术持续时间在2小时以内。术后,癫痫立即停止,婴儿发育和神经功能迅速改善,术后8个月无癫痫发作(目前为恩格尔1a级)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a338/12125049/030ade6054d9/381_2025_6857_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a338/12125049/8be730dd562c/381_2025_6857_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a338/12125049/030ade6054d9/381_2025_6857_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a338/12125049/8be730dd562c/381_2025_6857_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a338/12125049/030ade6054d9/381_2025_6857_Fig2_HTML.jpg

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本文引用的文献

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Burr Hole Hemispherotomy: Case Series.颅骨钻孔大脑半球切除术:病例系列
Oper Neurosurg. 2025 Oct 1;29(4):507-516. doi: 10.1227/ons.0000000000001527. Epub 2025 Mar 5.
2
Outcomes and complications of vertical parasagittal hemispherotomy in children: a nationwide population-based study.儿童垂直旁矢状位大脑半球切除术的结果与并发症:一项基于全国人口的研究。
J Neurosurg Pediatr. 2024 Oct 25;35(1):46-56. doi: 10.3171/2024.9.PEDS24281. Print 2025 Jan 1.
3
Pediatric peri-insular hemispherotomy and functional hemispherectomy for severe medically refractory epilepsy: comparison of two techniques.
儿童岛叶周围半球切开术和功能性大脑半球切除术治疗重度药物难治性癫痫:两种技术的比较。
Neurochirurgie. 2024 Nov;70(6):101594. doi: 10.1016/j.neuchi.2024.101594. Epub 2024 Sep 12.
4
Hippocampal resection during hemispherotomy: is it needed?脑半球离断术中行海马切除术:有必要吗?
Childs Nerv Syst. 2024 Dec;40(12):4169-4177. doi: 10.1007/s00381-024-06604-4. Epub 2024 Sep 7.
5
Surgical Anatomy and Technique of Peri-Insular Hemispherotomy in Pediatric Epilepsy.儿童癫痫岛叶周围脑半球切开术的外科解剖与技术
Oper Neurosurg (Hagerstown). 2024 Nov 1;27(5):608-617. doi: 10.1227/ons.0000000000001161. Epub 2024 Apr 23.
6
Epilepsy surgery in early infancy: A retrospective, multicenter study.婴儿期癫痫手术:一项回顾性多中心研究。
Epilepsia Open. 2023 Sep;8(3):1182-1189. doi: 10.1002/epi4.12791. Epub 2023 Jul 23.
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Functional hemispherotomy for epilepsy in the very young.针对幼儿癫痫的功能性大脑半球切除术
J Neurosurg Pediatr. 2022 Aug 5;30(4):400-409. doi: 10.3171/2022.6.PEDS21521. Print 2022 Oct 1.
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