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Ustekinumab Dose Optimization in Ulcerative Colitis: Is More Always Better?

作者信息

Chaemsupaphan Thanaboon, Limsrivilai Julajak

机构信息

Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, 2 Wanglang Road, Siriraj, Bangkoknoi, 10700, Bangkok, Thailand.

出版信息

Dig Dis Sci. 2025 May 31. doi: 10.1007/s10620-025-09108-6.

DOI:10.1007/s10620-025-09108-6
PMID:40447982
Abstract
摘要

相似文献

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本文引用的文献

1
Ustekinumab Trough Concentrations Are Associated with Biochemical Outcomes in Patients with Crohn's Disease.乌司奴单抗谷浓度与克罗恩病患者的生化结局相关。
Dig Dis Sci. 2023 Jun;68(6):2647-2657. doi: 10.1007/s10620-023-07822-7. Epub 2023 Mar 15.
2
Efficacy, Effectiveness, and Safety of Ustekinumab for the Treatment of Ulcerative Colitis: A Systematic Review.乌司奴单抗治疗溃疡性结肠炎的疗效、有效性和安全性:系统评价。
Inflamm Bowel Dis. 2024 Feb 1;30(2):292-302. doi: 10.1093/ibd/izac275.
3
Treat to target versus standard of care for patients with Crohn's disease treated with ustekinumab (STARDUST): an open-label, multicentre, randomised phase 3b trial.
靶向治疗与常规治疗对接受乌司奴单抗治疗的克罗恩病患者的疗效比较(STARDUST):一项开放标签、多中心、随机 3b 期试验。
Lancet Gastroenterol Hepatol. 2022 Apr;7(4):294-306. doi: 10.1016/S2468-1253(21)00474-X. Epub 2022 Feb 1.
4
Ustekinumab Pharmacokinetics and Exposure Response in a Phase 3 Randomized Trial of Patients With Ulcerative Colitis.乌司奴单抗药代动力学和在溃疡性结肠炎 3 期随机试验中的暴露反应。
Clin Gastroenterol Hepatol. 2020 Sep;18(10):2244-2255.e9. doi: 10.1016/j.cgh.2019.11.059. Epub 2019 Dec 7.
5
Ustekinumab as Induction and Maintenance Therapy for Ulcerative Colitis.乌司奴单抗诱导和维持溃疡性结肠炎的治疗。
N Engl J Med. 2019 Sep 26;381(13):1201-1214. doi: 10.1056/NEJMoa1900750.