Kandemir Emre, Kucuktopcu Onur
Faculty of Medicine, Department of Urology, Karamanoglu Mehmetbey University, Karaman, Turkey.
Clinic of Urology, Konya City Hospital, Konya, Turkey.
Pharmacol Res Perspect. 2025 Jun;13(3):e70129. doi: 10.1002/prp2.70129.
Our study aimed to examine medication adherence (MA) to tadalafil 5 mg once daily (OaD) in patients undergoing treatment for erectile dysfunction (ED) and to identify factors contributing to potential drug noncompliance. This cross-sectional study included 233 patients diagnosed with ED. Sociodemographic and clinical data were recorded. MA was assessed using the Medication Adherence Report Scale (MARS). Additionally, the Brief Illness Perception Questionnaire (B-IPQ), the Beliefs about Medicines Questionnaire (BMQ), and the International Index of Erectile Function (IIEF) were employed to evaluate patients' perceptions and beliefs regarding their condition and treatment. The influence of these factors on MA was thoroughly analyzed. High MA was reported in 136 (58.4%) of 233 patients. Factors, such as education level, monthly income, frequency of medical examinations, smoking habits, and a history of radical pelvic surgery, were found to influence MA (p < 0.05) significantly. Multivariate analysis identified monthly income and radical pelvic surgery history as statistically significant predictors of adherence (p ≤ 0.05). Additionally, adherence was significantly associated with IIEF scores, five items on the B-IPQ, and the BMQ subscales, including specific concerns, necessity, and general harm (p < 0.05). Tadalafil OaD demonstrates acceptable rates of MA in the treatment of ED. Socioeconomic and clinical factors, patients' cognitive and sensory status, and perceptions regarding medications and healthcare providers significantly influence adherence. Physicians should exercise caution when prescribing tadalafil 5 mg OaD to patients with lower socioeconomic status, as they may be at higher risk for reduced MA.
我们的研究旨在调查接受勃起功能障碍（ED）治疗的患者每日一次服用5毫克他达拉非的药物依从性（MA），并确定导致潜在药物不依从的因素。这项横断面研究纳入了233名被诊断为ED的患者。记录了社会人口统计学和临床数据。使用药物依从性报告量表（MARS）评估MA。此外，采用简短疾病认知问卷（B-IPQ）、药物信念问卷（BMQ）和国际勃起功能指数（IIEF）来评估患者对自身病情和治疗的认知及信念。对这些因素对MA的影响进行了全面分析。233名患者中有136名（58.4%）报告药物依从性高。发现教育水平、月收入、体检频率、吸烟习惯和根治性盆腔手术史等因素对MA有显著影响（p<0.05）。多变量分析确定月收入和根治性盆腔手术史是依从性的统计学显著预测因素（p≤0.05）。此外，依从性与IIEF评分、B-IPQ的五个项目以及BMQ子量表（包括特定担忧、必要性和一般危害）显著相关（p<0.05）。每日一次服用他达拉非在ED治疗中显示出可接受的MA率。社会经济和临床因素、患者的认知和感觉状态以及对药物和医疗服务提供者的认知显著影响依从性。医生在为社会经济地位较低的患者开具每日一次5毫克他达拉非处方时应谨慎，因为他们的MA降低风险可能更高。
