Department of General Surgery, Medipol University, Istanbul, Turkey.
Department of Internal Medicine, Medipol University, Istanbul, Turkey.
Head Neck. 2021 Feb;43(2):428-437. doi: 10.1002/hed.26488. Epub 2020 Oct 2.
To investigate medication adherence (MA) to Levothyroxine in differentiated thyroid cancer survivors and analyze the related factors for nonadherence.
The Medication Adherence Report Scale (MARS), Hospital Anxiety and Depression Scale (HAD), Brief Illness Perception Questionnaire (B-IPQ), and Beliefs about Medicines Questionnaire (BMQ) were used to assess MA.
Nonadherence was reported in 77 of 197 patients (39.1%). Socioeconomic status and education levels were found to be significantly related to MA. The HAD scores, all items of B-IPQ, and BMQ were associated with MA and showed a correlation with the MARS scores. The primary predictors of MA were greater confidence in treatment modality (odds ratio [OR]: 0.48, 95% confidence interval (CI): 0.37-0.63) and greater belief that the medication had minimal risk of harm (OR: 3.35, 95% CI: 1.50-7.49).
Special attention should be paid to educational programs for differentiated thyroid carcinoma patients concerning the effectiveness and low risk of harm of medication in order to improve MA.
调查分化型甲状腺癌幸存者对左甲状腺素的用药依从性（MA），并分析不依从的相关因素。
采用用药依从性报告量表（MARS）、医院焦虑抑郁量表（HAD）、简要疾病感知问卷（B-IPQ）和药物信念问卷（BMQ）评估 MA。
197 例患者中，77 例（39.1%）报告用药不依从。社会经济地位和教育水平与 MA 显著相关。HAD 评分、B-IPQ 的所有条目和 BMQ 与 MA 相关，并与 MARS 评分呈正相关。MA 的主要预测因素是对治疗方式的信心更高（比值比 [OR]：0.48，95%置信区间 [CI]：0.37-0.63）和对药物的伤害风险最小的信念更强（OR：3.35，95% CI：1.50-7.49）。
应特别关注分化型甲状腺癌患者的教育计划，使患者了解药物的有效性和低风险，以提高 MA。
