Zhao Er Juan, Khan Salman, Guo Hao, Sun Jia Lin, Zhu Ao, Jiao Rui Hua, Ge Hui Ming, Zhang Bo
State Key Laboratory of Pharmaceutical Biotechnology, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Life Sciences, Nanjing University, Nanjing 210023, China.
Org Lett. 2025 Jun 13;27(23):6071-6075. doi: 10.1021/acs.orglett.5c01652. Epub 2025 May 31.
Tetrodecamycins represent a distinctive class of tetronate natural products characterized by a unique polycyclic architecture, in which a dialkyldecalin core is bridged to the γ-lactone tetronate moiety via a rare ether linkage. Through gene deletions, intermediate structural characterizations, and enzymatic assays, we elucidated the dihydrotetrodecamycin biosynthetic pathway. Notably, the cytochrome P450 enzyme, TedH, catalyzes both ether bridge formation and regio/stereoselective C-13 hydroxylation to construct the intricate polycyclic ring system.
十四元霉素代表了一类独特的四内酯天然产物，其特征在于独特的多环结构，其中二烷基十氢化萘核心通过罕见的醚键与γ-内酯四内酯部分相连。通过基因缺失、中间结构表征和酶促试验，我们阐明了二氢十四元霉素的生物合成途径。值得注意的是，细胞色素P450酶TedH催化醚桥形成以及区域/立体选择性C-13羟基化，以构建复杂的多环系统。
