Blood and Peritoneal Lactate, Ratio and Difference, and Peritoneal Lactate to Total Solids Ratio for Detection of Intestinal Strangulating Obstructions in Horses.

BACKGROUND

The effectiveness of the peritoneal fluid L-lactate-to-total solids ratio (PFL:PFTS) as a diagnostic marker for strangulating lesions of the small intestine (SI) and large colon (LC) has not been investigated.

OBJECTIVES

Describe and compare the PFL:PTFS and blood lactate (BL), peritoneal fluid lactate (PFL) and PFL:BL difference and PFL:BL ratio of horses with SI and LC strangulating (SO) and non-strangulating (NSO) obstructions and determine sensitivity and specificity to predict SO.

ANIMALS

A total of 282 horses, 117 with SI lesions (59 classified as SINSO and 58 as SISO), and 165 with LC lesions, 126 categorized as LCNSO and 39 as LCSO.

METHODS

Retrospective study. Receiver operating characteristic (ROC) curves were generated to identify optimal cut-off points to maximize sensitivity and specificity to predict SO.

RESULTS

A PFL:PFTS ratio of 2.9 had fair (area under the curve [AUC], 0.76; 95% confidence interval [CI], 0.67-0.84) ability to discriminate between SISO and SINSO, with sensitivity of 66.7% and specificity of 78.3% to predict SISO.

A PFL

PFTS ratio of 3.6 had good ability to discriminate between LCSO and LCNSO (AUC, 0.84; 95% CI, 0.78-0.90) with sensitivity and specificity of 78% and 81% to predict LCSO, respectively. Peritoneal fluid lactate, PFL:BL difference, and PFL:BL ratio also had a low to moderate sensitivity to predict ischemic strangulating lesions of the SI and LC.

CONCLUSION AND CLINICAL IMPORTANCE

Strangulating obstructions are critical conditions requiring prompt intervention. The low to moderate sensitivity identified suggests that PFL, PFL:BL difference and ratio, and PFL:PFTS ratio should be interpreted with clinical signs and the response to initial treatment to determine SO accurately.