Li Y, Du X, Geng Z
Medical Imaging Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075061, Hebei, China; Department of Medical Imaging, The Second Hospital of Hebei Medical University, Shijiazhuang, 050061, Hebei, China.
Radiotherapy Department, The First Affiliated Hospital of Hebei North University, Zhangjiakou, 075061, Hebei, China.
Clin Radiol. 2025 Jul;86:106939. doi: 10.1016/j.crad.2025.106939. Epub 2025 Apr 24.
Investigating the diagnostic value of quantitative brain synthetic magnetic resonance imaging (SyMRI) in adult patients with obstructive sleep apnoea (OSA) and brain microstructural injury.
Fifty untreated OSA patients at initial diagnosis who were diagnosed were collected as the OSA group, with 36 non-OSA patients as the normal group. Afterwards, all subjects underwent cranial scans using GE SIGNA Architect 3.0T magnetic resonance imaging. Meanwhile, the differences in grey matter relaxation values, white matter relaxation values, and proton density (PD) values between the 2 groups were compared, followed by an analysis of the correlation between the above parameters and apnoea-hypopnoea index (AHI).
Compared with the normal group, T2 values of grey and white matter were significantly decreased, and T1 and PD values of grey matter were slightly decreased in the OSA group, with significant differences (P<005). In the meantime, receiver operating characteristic curves suggested the highest area under the curve (AUC) (0.74) and a high sensitivity (92.0%) of T2 values of white matter, along with a low specificity (52.0%). Additionally, the T1 and T2 values of grey matter shared the same AUC (0.69), which exhibited high specificity (75.0%) and high sensitivity (92.0%), respectively. Furthermore, Spearman correlation analysis indicated that T1 values of grey matter were positively correlated with AHI, while T2 values of grey and white matter were negatively correlated with AHI (P<0.05).
SyMRI quantitative imaging parameters are of significant clinical value for adult OSA patients, especially T2 relaxation values, which are beneficial for the early diagnosis of brain microstructural injury.
探讨定量脑合成磁共振成像（SyMRI）在成年阻塞性睡眠呼吸暂停（OSA）患者及脑微结构损伤中的诊断价值。
收集50例初诊未治疗的OSA患者作为OSA组，36例非OSA患者作为正常组。之后，所有受试者均采用GE SIGNA Architect 3.0T磁共振成像进行头颅扫描。同时，比较两组之间灰质弛豫值、白质弛豫值和质子密度（PD）值的差异，随后分析上述参数与呼吸暂停低通气指数（AHI）之间的相关性。
与正常组相比，OSA组灰质和白质的T2值显著降低，灰质的T1值和PD值略有降低，差异有统计学意义（P<0.05）。同时，受试者工作特征曲线显示白质T2值的曲线下面积（AUC）最高（0.74），敏感性较高（92.0%），但特异性较低（52.0%）。此外，灰质的T1值和T2值的AUC相同（0.69），分别表现出高特异性（75.0%）和高敏感性（92.0%）。此外，Spearman相关性分析表明，灰质的T1值与AHI呈正相关，而灰质和白质的T2值与AHI呈负相关（P<0.05）。
SyMRI定量成像参数对成年OSA患者具有重要临床价值，尤其是T2弛豫值，有利于脑微结构损伤的早期诊断。
