Su Yanfeng, Wu Ruji, Yuan Haofeng, He Jiawei, Pan Huien
Affiliated Dongguan Songshan Lake Central Hospital, Urology Department, Guangdong Medical University, Dongguan, China.
Sci Rep. 2025 May 31;15(1):19116. doi: 10.1038/s41598-025-03034-3.
This study investigated the association between the weight-adjusted waist circumference index (WWI) and the prevalence of kidney stones among U.S. adults with diabetes, addressing the knowledge gap regarding the role of central obesity in kidney stone formation. Using data from the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2018, we analyzed 21,177 participants. The WWI served as the exposure variable, whereas kidney stones were the outcome variable. Multiple regression and mediation effect analyses were employed to assess the mediating role of diabetes in the relationship between WWI and kidney stones. Among the 21,177 participants analyzed, each unit increase in the weight-adjusted waist circumference index (WWI) was associated with a 30% higher incidence of kidney stones (OR = 1.30, 95% CI 1.21-1.39; P < 0.0001). Participants in the highest WWI tertile exhibited a 66% increased risk of kidney stones compared to those in the lowest tertile (OR = 1.66, 95% CI 1.43-1.93; P < 0.0001). The diabetes mediating 12.60% of this association (95% CI 8.2-17.8%, P < 0.0001). The WWI is independently associated with an increased risk of kidney stones, with diabetes playing a partial mediating role. These findings highlight the importance of monitoring WWI as a potential risk factor for kidney stones, especially in populations with diabetes.
本研究调查了美国糖尿病成年人中体重调整腰围指数（WWI）与肾结石患病率之间的关联，填补了关于中心性肥胖在肾结石形成中作用的知识空白。利用2007年至2018年美国国家健康与营养检查调查（NHANES）的数据，我们分析了21177名参与者。WWI作为暴露变量，而肾结石作为结果变量。采用多元回归和中介效应分析来评估糖尿病在WWI与肾结石关系中的中介作用。在分析的21177名参与者中，体重调整腰围指数（WWI）每增加一个单位，肾结石发病率就会高出30%（OR = 1.30，95% CI 1.21 - 1.39；P < 0.0001）。与最低三分位数组的参与者相比，最高WWI三分位数组的参与者患肾结石的风险增加了66%（OR = 1.66，95% CI 1.43 - 1.93；P < 0.0001）。糖尿病介导了这种关联的12.60%（95% CI 8.2 - 17.8%，P < 0.0001）。WWI与肾结石风险增加独立相关，糖尿病起部分中介作用。这些发现凸显了监测WWI作为肾结石潜在危险因素的重要性，尤其是在糖尿病患者群体中。
