Manoharan Ragavan, Srikandarajah Nisaharan, Murray Jean-Christophe, Nielsen Christopher, Singh Supriya, Christie Sean, Yang Michael M H, Weber Michael, Larue Bernard, Kelly Adrienne, Paquet Jerome, Charest-Morin Raphaele, Hogan Guy, Glennie Andrew, Anh Henry, Wai Eugene, Dea Nicolas, Mason Neil, Thomas Kenneth, Fisher Charles, Hall Hamilton, Bailey Christopher, Canizares Mayilee, Rampersaud Yoga Raja
University of Toronto Spine Program, Toronto Western Hospital, Toronto, ON, Canada.
Department of Neurosurgery, Royal North Shore Hospital, Sydney, Australia.
Sci Rep. 2025 May 31;15(1):19143. doi: 10.1038/s41598-025-03613-4.
The impact of spine surgery on Health-Related Quality-of-Life (HRQoL) outcomes across common spinal degenerative diagnoses is not well characterised. A prospective observational study of patients enrolled in the Canadian Spine Outcomes and Research Network (CSORN) registry was performed. Baseline and 1-year post-operative Short Form-12 Physical Component Summary (PCS) and Mental Component Summary (MCS) scores were collated and compared to normative values from the Canadian General Population (CGP). The percentage of patients achieving the PCS Minimum Clinically Important Difference (MCID) was quantified. 5049 patients were included in the analysis. The mean pre-operative SF-12 PCS was 29.5 and MCS was 44.1. This improved to a mean PCS of 40.5 (p < 0.001) and MCS of 49.3 (p < 0.0001) at 1-year post-operatively. The mean pre-operative PCS was over 2 standard deviations (SD) lower than the normative mean of the CGP; this improved to being close to 1-SD from the normative CGP mean at 1-year post-operatively. Findings were similar across age- and sex-stratified subgroups. Across all conditions, 70-75% of patients achieved the PCS MCID. Fewer patients with cervical myelopathy achieved the PCS MCID (59%). In a surgical cohort, patients with degenerative spinal conditions demonstrate a profound reduction in PCS compared to their peers in the CGP. Spinal surgery was impactful in improving physical function HRQoL outcomes in the majority, but not typically to average population norms.
脊柱手术对常见脊柱退行性疾病患者健康相关生活质量（HRQoL）结果的影响尚未得到充分描述。我们对纳入加拿大脊柱结局与研究网络（CSORN）登记处的患者进行了一项前瞻性观察研究。整理并比较了患者术前及术后1年的简明健康调查问卷12项身体成分总结（PCS）和精神成分总结（MCS）评分与加拿大普通人群（CGP）的标准值。对达到PCS最小临床重要差异（MCID）的患者百分比进行了量化。5049例患者纳入分析。术前SF-12 PCS平均分为29.5，MCS平均分为44.1。术后1年，这一评分分别提高至PCS平均分为40.5（p<0.001），MCS平均分为49.3（p<0.0001）。术前PCS平均分比CGP标准平均分低超过2个标准差（SD）；术后1年，这一评分提高至接近CGP标准平均分1个标准差。不同年龄和性别的亚组结果相似。在所有疾病中，70-75%的患者达到了PCS MCID。脊髓型颈椎病患者达到PCS MCID的比例较低（59%）。在手术队列中，与CGP中的同龄人相比，患有退行性脊柱疾病的患者PCS显著降低。脊柱手术对改善大多数患者的身体功能HRQoL结果有显著影响，但通常未达到普通人群的标准。
