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靶向聚（ADP-核糖）聚合酶1的α疗法可增强靶标表达。

PARP1-targeted alpha therapy enhances target expression.

作者信息

Babazada Hasan, Martorano Paul, Lee Hsiaoju, Geng Shuyao, Batra Vandana, Maris John M, Pryma Daniel A, Gitto Sarah B, Farwell Michael D

机构信息

Perelman School of Medicine at the University of Pennsylvania, 3620 Hamilton Walk, John Morgan Bldg., Philadelphia, PA, 19104, USA.

Children's Hospital of Philadelphia, Philadelphia, PA, USA.

出版信息

EJNMMI Res. 2025 Jun 1;15(1):63. doi: 10.1186/s13550-025-01256-0.

DOI:10.1186/s13550-025-01256-0
PMID:40450628
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12127250/
Abstract

UNLABELLED: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13550-025-01256-0.

摘要

未标注：[图片：见正文] 补充信息：在线版本包含可在10.1186/s13550-025-01256-0获取的补充材料。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/3e69eadc14d1/13550_2025_1256_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/a31e9b298a85/13550_2025_1256_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/0b7fcd2cdf8a/13550_2025_1256_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/797902b66169/13550_2025_1256_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/3e69eadc14d1/13550_2025_1256_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/a31e9b298a85/13550_2025_1256_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/0b7fcd2cdf8a/13550_2025_1256_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/797902b66169/13550_2025_1256_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4659/12127250/3e69eadc14d1/13550_2025_1256_Fig4_HTML.jpg

相似文献

[1]
PARP1-targeted alpha therapy enhances target expression.

EJNMMI Res. 2025-6-1

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
gene polymorphisms and neuroblastoma susceptibility in Chinese children.

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[8]
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[9]
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[10]
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Nat Commun. 2025-3-25

本文引用的文献

[1]
[I]CC1: A PARP-Targeting, Auger Electron-Emitting Radiopharmaceutical for Radionuclide Therapy of Cancer.

J Nucl Med. 2023-12-1

[2]
Therapy resistance in neuroblastoma: Mechanisms and reversal strategies.

Front Pharmacol. 2023-2-16

[3]
[18F]FluorThanatrace ([18F]FTT) PET Imaging of PARP-Inhibitor Drug-Target Engagement as a Biomarker of Response in Ovarian Cancer, a Pilot Study.

Clin Cancer Res. 2023-4-14

[4]
Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma.

Commun Biol. 2022-11-17

[5]
[F]-Labeled PARP-1 PET imaging of PSMA targeted alpha particle radiotherapy response.

Sci Rep. 2022-7-29

[6]
Emerging therapeutic targets for neuroblastoma.

Expert Opin Ther Targets. 2020-9

[7]
Development of Targeted Alpha Particle Therapy for Solid Tumors.

Molecules. 2019-11-26

[8]
Targeting PARP-1 with Alpha-Particles Is Potently Cytotoxic to Human Neuroblastoma in Preclinical Models.

Mol Cancer Ther. 2019-5-9

[9]
Rapid Cu-Catalyzed [At]Astatination and [I]Iodination of Boronic Esters at Room Temperature.

Org Lett. 2018-3-21

[10]
A PET imaging agent for evaluating PARP-1 expression in ovarian cancer.

J Clin Invest. 2018-4-16

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