Notch信号通路：神经发生过程中细胞命运的守护者。
The Notch pathway: A guardian of cell fate during neurogenesis.
作者信息
Gonzalez Rene, Reinberg Danny
机构信息
Howard Hughes Medical Institute, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
Howard Hughes Medical Institute, University of Miami, Miami, FL 33136, USA; Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, FL 33136, USA; Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA.
出版信息
Curr Opin Cell Biol. 2025 Aug;95:102543. doi: 10.1016/j.ceb.2025.102543. Epub 2025 Jun 2.
The Notch signaling pathway is essential for cell fate decisions and maintaining epigenetic memory during nervous system development. It regulates neural stem cell maintenance, neuronal-glial differentiation, and neural circuit formation. Notch activation, through ligand-receptor interactions, releases the Notch intracellular domain, which modulates gene expression in the nucleus. This context-dependent regulation allows Notch to balance proliferation and differentiation, integrating with other pathways and epigenetic regulators to preserve neural stem cell identity and respond to environmental cues. Notch signaling dysfunction is linked to various neurological disorders, highlighting its critical role in nervous system development and homeostasis. This review explores the multifaceted functions of Notch signaling, emphasizing its impact on cell fate and epigenetic memory in early neurogenesis and the adult brain.
Notch信号通路对于神经系统发育过程中的细胞命运决定和维持表观遗传记忆至关重要。它调节神经干细胞的维持、神经元-胶质细胞分化以及神经回路的形成。通过配体-受体相互作用激活Notch，释放Notch细胞内结构域，该结构域可调节细胞核中的基因表达。这种依赖于上下文的调节使Notch能够平衡增殖和分化，与其他信号通路和表观遗传调节因子整合，以维持神经干细胞的特性并响应环境信号。Notch信号功能障碍与多种神经系统疾病相关，突显了其在神经系统发育和稳态中的关键作用。本综述探讨了Notch信号通路的多方面功能，强调了其在早期神经发生和成年大脑中对细胞命运和表观遗传记忆的影响。
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