Courtney K D, Andrews J E, Springer J, Dalley L
J Environ Sci Health B. 1985 Aug;20(4):373-406. doi: 10.1080/03601238509372485.
Baygon was administered IG once daily to CD rats (5 to 50 mg/kg), on the 7th-19th day of gestation or to CD-1 mice (5 to 60 mg/kg) on days 6-16 of gestation. Baygon, at dose levels which were not maternally lethal, did not produce fetotoxicity, fetal lethality or malformations in the fetuses. Baygon was not teratogenic in the CD rat or CD-1 mouse at maternally nontoxic dose levels. Carbofuran was administered IG once daily to CD rats (0.05 to 5.0 mg/kg), on the 7th-19th day of gestation or to CD-1 mice (0.1 to 20 mg/kg) on days 6-16 of gestation. At dose levels which were not maternally lethal, carbofuran did not produce fetotoxicity, fetal lethality or malformations in the fetuses. Carbofuran was not teratogenic in the CD rat or CD-1 mouse at maternally nontoxic dose levels. Dimethoate was administered IG once daily to CD-1 mice (10 to 80 mg/kg), on the 6th-16th day of gestation. At dose levels which were not maternally lethal, dimethoate did not produce fetotoxicity, fetal lethality or malformations in the fetuses. Dimethoate was not teratogenic in the CD-1 mouse at maternally nontoxic dose levels. EPN was administered IG once daily to CD-1 mice (1.0 to 12.0 mg/kg) on the 6th-16th day of gestation. EPN, at dose levels up to those which were maternally lethal, did not produce fetotoxicity, fetal lethality or an increase in malformations. EPN was not teratogenic in the CD-1 mouse at maternally nontoxic dose levels.
在妊娠第7至19天，将拜戈以每日一次的剂量灌胃给予CD大鼠（5至50毫克/千克），或在妊娠第6至16天给予CD - 1小鼠（5至60毫克/千克）。在未产生母体致死效应的剂量水平下，拜戈未对胎儿产生胚胎毒性、胎儿致死性或畸形。在母体无毒剂量水平下，拜戈对CD大鼠或CD - 1小鼠无致畸性。在妊娠第7至19天，将呋喃丹以每日一次的剂量灌胃给予CD大鼠（0.05至5.0毫克/千克），或在妊娠第6至16天给予CD - 1小鼠（0.1至20毫克/千克）。在未产生母体致死效应的剂量水平下，呋喃丹未对胎儿产生胚胎毒性、胎儿致死性或畸形。在母体无毒剂量水平下，呋喃丹对CD大鼠或CD - 1小鼠无致畸性。在妊娠第6至16天，将乐果以每日一次的剂量灌胃给予CD - 1小鼠（10至80毫克/千克）。在未产生母体致死效应的剂量水平下，乐果未对胎儿产生胚胎毒性、胎儿致死性或畸形。在母体无毒剂量水平下，乐果对CD - 1小鼠无致畸性。在妊娠第6至16天，将EPN以每日一次的剂量灌胃给予CD - 1小鼠（1.0至12.0毫克/千克）。在达到母体致死剂量水平之前，EPN未对胎儿产生胚胎毒性、胎儿致死性或畸形增加。在母体无毒剂量水平下，EPN对CD - 1小鼠无致畸性。
