Courtney K D, Andrews J E, Springer J
J Environ Sci Health B. 1986 Jun;21(3):207-27. doi: 10.1080/03601238609372519.
Trichlorfon was evaluated for its teratogenic potential in the CD-1 mouse at doses of 200, 300 or 400 mg/kg/day administered by gavage on days 7-16 of gestation. In the CD-1 mouse, TCF was teratogenic, fetotoxic and lethal at the two highest dose levels which were also maternally lethal. At the lowest dose level which was not maternally lethal, there was a significant decrease in the number of calcified centers in the forepaws and hindpaws indicating fetotoxicity and a delay in maturation. TCF was administered at doses of 50, 100 or 200 mg/kg/day to CD rats by gavage on gestational days 7-19 (study I) or 8-20 (study II). In the CD rat in body study I and II, the highest dose level was maternally lethal. In study I, TCF was teratogenic with a shift in rib profile. In study II, TCF was teratogenic with an increased incidence in malformations of the urinary system. Additionally, TCF was fetotoxic with reduced ossification of the skulls at the lowest and highest dose levels.
在妊娠第7至16天，通过灌胃法给CD-1小鼠分别以200、300或400mg/kg/天的剂量施用敌百虫，对其致畸潜力进行评估。在CD-1小鼠中，在两个最高剂量水平时，敌百虫具有致畸性、胚胎毒性和致死性，且这两个剂量水平对母体也具有致死性。在对母体无致死性的最低剂量水平时，前爪和后爪的钙化中心数量显著减少，表明存在胚胎毒性以及成熟延迟。在妊娠第7至19天（研究I）或第8至20天（研究II），通过灌胃法给CD大鼠分别以50、100或200mg/kg/天的剂量施用敌百虫。在CD大鼠的研究I和II中，最高剂量水平对母体具有致死性。在研究I中，敌百虫具有致畸性，伴有肋骨形态改变。在研究II中，敌百虫具有致畸性，泌尿系统畸形发生率增加。此外，在最低和最高剂量水平时，敌百虫具有胚胎毒性，表现为颅骨骨化减少。
