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线粒体生物合成：线粒体蛋白质合成抑制剂

Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.

作者信息

Wilkie D

出版信息

Mol Cell Biochem. 1977 Feb 4;14(1-3):97-100. doi: 10.1007/BF01734171.

DOI:10.1007/BF01734171
PMID:404520
Abstract

The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. The data are discussed.

摘要

研究了红霉素、氯霉素、放线菌酮、乙胺嘧啶、铬酸盐、镉、铅、镍、4-硝基喹啉-1-氧化物和硫代乙酰胺对酵母细胞和人体细胞的影响。线粒体蛋白质合成的抑制导致细胞色素的丧失，以及细胞膜的形态变化和有丝分裂停滞。对这些数据进行了讨论。

相似文献

1
Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.线粒体生物合成：线粒体蛋白质合成抑制剂
Mol Cell Biochem. 1977 Feb 4;14(1-3):97-100. doi: 10.1007/BF01734171.
2
The biogenesis of a cytochrome b complex in yeast mitochondria. Sites of translation of the protein components.酵母线粒体中细胞色素b复合体的生物合成。蛋白质组分的翻译位点。
Arch Biochem Biophys. 1976 Feb;172(2):679-84. doi: 10.1016/0003-9861(76)90123-5.
3
Loss of cytochrome oxidase in Saccharomyces cerevisiae during inhibition of mitochondrial protein synthesis by erythromycin and chloramphenicol.在红霉素和氯霉素抑制线粒体蛋白质合成过程中酿酒酵母细胞色素氧化酶的丧失
J Gen Microbiol. 1975 Nov;91(1):150-6. doi: 10.1099/00221287-91-1-150.
4
In vivo differentiation of yeast cytoplasmic and mitochondrial protein synthesis with antibiotics.利用抗生素对酵母细胞质和线粒体蛋白质合成进行体内分化
Biochem Biophys Res Commun. 1966 Oct 5;25(1):8-13. doi: 10.1016/0006-291x(66)90631-0.
5
The dependence of cytosole protein biosynthesis resistance to cycloheximide in yeast on changes in mitochondrial activity.酵母细胞溶质蛋白生物合成对放线菌酮的抗性与线粒体活性变化的关系。
Mol Gen Genet. 1974 Mar 27;129(3):243-8. doi: 10.1007/BF00267916.
6
Subunit composition and biogenesis of mitochondrial cytochrome b.线粒体细胞色素b的亚基组成与生物合成
Biochim Biophys Acta. 1976 Nov 30;456(3-4):291-313. doi: 10.1016/0304-4173(76)90002-1.
7
Formation of the yeast mitochondrial membrane. 2. Effects of glucose repression on mitochondrial protein synthesis.酵母线粒体膜的形成。2. 葡萄糖阻遏对线粒体蛋白质合成的影响。
Eur J Biochem. 1973 Jul 16;36(2):519-27. doi: 10.1111/j.1432-1033.1973.tb02938.x.
8
Electrophoretic behavior of cytochrome b in a partially purified preparation and evidence for high molecular weight associated mitochondrial translation products.细胞色素b在部分纯化制剂中的电泳行为及高分子量相关线粒体翻译产物的证据。
Biochemistry. 1979 May 29;18(11):2400-6. doi: 10.1021/bi00578a040.
9
A novel respiration-deficient mutant of Saccharomyces cerevisiae. I. Preliminary characterization of phenotype and mitochondrial inheritance.酿酒酵母一种新型呼吸缺陷型突变体。I. 表型及线粒体遗传的初步特征分析
J Biol Chem. 1974 Oct 10;249(19):6130-7.
10
Regulation of mitochondrial protein synthesis at the polyribosomal level.多核糖体水平上的线粒体蛋白质合成调控
J Biol Chem. 1976 Jan 10;251(1):108-15.

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Plant Signal Behav. 2009 Jan;4(1):75-7. doi: 10.4161/psb.4.1.7419.
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Treating critical illness: the importance of first doing no harm.治疗危重病：首要原则是不伤害的重要性。
PLoS Med. 2005 Jun;2(6):e167. doi: 10.1371/journal.pmed.0020167. Epub 2005 Jun 28.
3
Biosynthesis of mitochondrial membrane proteins: co-ordination with special reference to cytochrome c oxidase.线粒体膜蛋白的生物合成：特别是细胞色素c氧化酶的协同作用

本文引用的文献

1
Induction of the cytoplasmic petite mutation in Saccharomyces cerevisiae by the antibacterial antibiotics erythromycin and chloramphenicol.抗菌抗生素红霉素和氯霉素诱导酿酒酵母细胞质小菌落突变
Mol Gen Genet. 1971;111(3):209-23. doi: 10.1007/BF00433106.
2
Endogenous systhesis of formyl-methionine peptides in isolated mitochondria and chloroplasts.分离的线粒体和叶绿体中甲酰甲硫氨酸肽的内源性合成。
Biochem Biophys Res Commun. 1971 Jan 8;42(1):97-102. doi: 10.1016/0006-291x(71)90367-6.
3
Cellular and mitochondrial effects of folate antagonism by pyrimethamine in Saccharomyces cerevisiae.
Mol Cell Biochem. 1978 May 31;19(3):135-46. doi: 10.1007/BF00225451.
乙胺嘧啶对酿酒酵母叶酸拮抗作用的细胞及线粒体效应
J Gen Microbiol. 1974 Aug;83(2):283-93. doi: 10.1099/00221287-83-2-283.
4
Biogenetic autonomy of mitochondria.线粒体的生物遗传自主性
CRC Crit Rev Biochem. 1973 Aug;1(3):381-460. doi: 10.3109/10409237309105439.
5
Stabilization of the enzymatic systems of the inner mitochondrial membrane and related problems. A possible approach to the problem of the regulation of mitochondrial formation.线粒体内膜酶系统的稳定及相关问题。线粒体形成调控问题的一种可能解决方法。
Subcell Biochem. 1973 Jan;2(1):1-31.
6
Mitochondrial nucleic acids.线粒体核酸
Annu Rev Biochem. 1972;41:333-76. doi: 10.1146/annurev.bi.41.070172.002001.
7
Biosynthesis of mitochondrial enzymes.线粒体酶的生物合成
Biochim Biophys Acta. 1973 Feb 12;301(1):71-104. doi: 10.1016/0304-4173(73)90013-x.
8
Induction of mitochondrial RNA polymerase in Neurospora crassa.粗糙脉孢菌中线粒体RNA聚合酶的诱导
Nat New Biol. 1972 Dec 13;240(102):195-7. doi: 10.1038/newbio240195a0.
9
Cytochrome b in Neurospora crassa mitochondria. A membrane protein containing subunits of cytoplasmic and mitochondrial origin.粗糙脉孢菌线粒体中的细胞色素b。一种包含细胞质和线粒体来源亚基的膜蛋白。
Eur J Biochem. 1972 Nov 7;30(3):469-78. doi: 10.1111/j.1432-1033.1972.tb02119.x.
10
Limited ability of thymidine to relieve mitotic inhibition by pyrimethamine in human fibroblasts.胸苷缓解乙胺嘧啶对人成纤维细胞有丝分裂抑制作用的能力有限。
Biochem Pharmacol. 1976 Mar 15;25(6):681-5. doi: 10.1016/0006-2952(76)90244-6.