线粒体生物合成：线粒体蛋白质合成抑制剂
Mitochondrial biogenesis: inhibitors of mitochondrial protein synthesis.
作者信息
Wilkie D
出版信息
Mol Cell Biochem. 1977 Feb 4;14(1-3):97-100. doi: 10.1007/BF01734171.
PMID:404520
Abstract
The effects of erythromycin, chloramphenicol, cycloheximide, pyrimethamine, chromate, cadmium, lead, nickel, 4-nitro-quinoline-1-oxide and thioacetamide on yeast and human cells were studied. Inhibition of the synthesis of mitochondrial proteins resulted in the loss of cytochromes as well as in morphological changes in the cellular membranes and mitotic arrest. The data are discussed.
摘要
研究了红霉素、氯霉素、放线菌酮、乙胺嘧啶、铬酸盐、镉、铅、镍、4-硝基喹啉-1-氧化物和硫代乙酰胺对酵母细胞和人体细胞的影响。线粒体蛋白质合成的抑制导致细胞色素的丧失，以及细胞膜的形态变化和有丝分裂停滞。对这些数据进行了讨论。
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