2014年至2024年东非牛口蹄疫血清流行率：系统评价与荟萃分析

Seroprevalence of foot and mouth disease in cattle in East Africa between 2014 and 2024: a systematic review and meta-analysis.

作者信息

Dagnaw Gashaw Getaneh, Dejene Haileyesus

机构信息

Department of Biomedical Sciences, College of Veterinary Medicine and Animal Science, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

Department of Veterinary Epidemiology and Public Health, College of Veterinary Medicine and Animal Science, University of Gondar, P.O. Box 196, Gondar, Ethiopia.

出版信息

BMC Vet Res. 2025 Jun 2;21(1):395. doi: 10.1186/s12917-025-04834-5.

DOI:10.1186/s12917-025-04834-5

PMID:40452018

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128236/

Abstract

BACKGROUND

Foot and mouth disease (FMD) is one of the most important transboundary animal diseases, causing severe economic losses due to high morbidity and export trade restrictions. Understanding the epidemiology of FMD is crucial to planning effective prevention and control measures. This study aimed to consolidate the seroprevalence estimates of FMD in different East African countries.

METHODS

The study was conducted following the Preferred Reporting Items for Systematic Review and meta-analysis guidelines. The research articles were searched from PubMed, Web of Sciences, Scopus, and Google Scholar databases using MeSH terms such as seroprevalence, FMD, East Africa, Cattle, and Eastern African countries. Studies published between 2014 and 2024 in the English language were included. For the assessment of publication bias and small study effects, funnel plots and Egger’s regression tests were used. The pooled seroprevalence was calculated with a 95% confidence interval using R software version 4.4.1.

RESULT

A total of 22 published articles were included in this meta-analysis and resulted in a pooled seroprevalence estimate of 43% (95% CI: 33.0, 53.0) for FMD. Subgroup analysis revealed substantial heterogeneity between countries ( = 0.0439, = 99.7%, Q-test = 22.89, df = 6, ≤ 0.001).

CONCLUSION

The current results demonstrate a high seroprevalence of FMD in the region. Given the significant economic impact of FMD, region-wide strategies aimed at reducing its prevalence and burden should be prioritized and supported with adequate funding.

SUPPLEMENTARY INFORMATION

The online version contains supplementary material available at 10.1186/s12917-025-04834-5.

摘要

背景

口蹄疫（FMD）是最重要的跨境动物疾病之一，由于高发病率和出口贸易限制导致严重的经济损失。了解口蹄疫的流行病学对于规划有效的预防和控制措施至关重要。本研究旨在汇总不同东非国家口蹄疫的血清流行率估计值。

方法

该研究按照系统评价和荟萃分析的首选报告项目指南进行。使用血清流行率、口蹄疫、东非、牛和东非国家等医学主题词从PubMed、科学网、Scopus和谷歌学术数据库中搜索研究文章。纳入2014年至2024年以英文发表的研究。为评估发表偏倚和小研究效应，使用了漏斗图和埃格回归检验。使用R软件版本4.4.1计算合并血清流行率及其95%置信区间。