Yang Pengfei, Zhang Shuang, Yin Xiaorong, Zhang Yaru, Zhu Haoran, Cao Yong, Shen Cheng
Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China.
Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.
Eur J Med Res. 2025 Jun 2;30(1):443. doi: 10.1186/s40001-025-02703-3.
Myocardial infarction with nonobstructive coronary arteries (MINOCA) refers to myocardial infarction cases with less than 50% narrowing of coronary arteries, accounting for about 2% to 10% of acute myocardial infarction cases, mainly in females. While MINOCA typically has a more favorable prognosis compared to obstructive CAD, the negative effects of MINOCA must not be overlooked. By amalgamating contemporary research on MINOCA, this study systematically delineates its progression, encompassing plaque lesions, coronary artery dissection, coronary microvascular spasm, thromboembolism, among others, various diagnostic techniques (such as coronary angiography, intravascular ultrasound, etc.) plus therapeutic approaches (such as statins, calcium channel blockers, antiplatelet medications, etc.). After pinpointing MINOCA's origin via supplementary correlative assessments, tailored treatment approaches become essential. In addition, this review also emphasizes current experiments that could offer fresh perspectives on treating MINOCA.
非阻塞性冠状动脉心肌梗死（MINOCA）是指冠状动脉狭窄小于50%的心肌梗死病例，约占急性心肌梗死病例的2%至10%，主要发生在女性中。虽然与阻塞性冠心病相比，MINOCA通常预后较好，但其负面影响不容忽视。通过整合当代关于MINOCA的研究，本研究系统地描述了其发病过程，包括斑块病变、冠状动脉夹层、冠状动脉微血管痉挛、血栓栓塞等，各种诊断技术（如冠状动脉造影、血管内超声等）以及治疗方法（如他汀类药物、钙通道阻滞剂、抗血小板药物等）。通过补充相关评估确定MINOCA的病因后，量身定制的治疗方法至关重要。此外，本综述还强调了当前可能为MINOCA治疗提供新视角的实验。
