Department of Dermatology, Yi Wu Skin Disease Hospital &Yi Wu Chou Jiang Community Healthcare Center, Yiwu, China.
Department of Dermatology, Hangzhou Jia Yun Medical Beauty Clinic, Hangzhou, China.
J Cosmet Laser Ther. 2025;27(4-5):166-172. doi: 10.1080/14764172.2025.2513380. Epub 2025 Jun 2.
Periorbital skin photoaging is a common cosmetic problem.Presently, conventional treatment methods cannot achieve satisfactory results. Periorbital skin aging may benefit from platelet-rich plasma (PRP) injection. However, there is little experimental evidence on the safety and efficacy of PRP in the treatment of periorbital skin photoaging. To examine the safety and efficacy of PRP injection in the treatment of periorbital skin photoaging, PRP was injected into the periorbital skin of 20 patients, and patient satisfaction was assessed at the first month (M1), the second month (M2), and the third month (M3) after treatment. Two experienced dermatologists independently evaluated the patient's skin before and after treatment according to internationally accepted guidelines. The objective indicators of skin hydration, melanin index, erythema index, skin brightness, transepidermal water loss (TEWL), skin elasticity, and skin thickness were measured. Some subjective indicators, including pigmentation around the eyes, suborbital wrinkles, and static crow's feet, were significantly improved. Some objective indicators, including skin brightness, skin thickness, and collagen strength, were also significantly improved. Eye bags and TEWL slightly improved, but the differences were not statistically significant. The overall patient satisfaction with the treatment was high, no serious complications were noted, and the recovery profile was favorable. PRP injection was safe and effective for the treatment of periorbital skin photoaging.
眶周皮肤光老化是一个常见的美容问题。目前，传统治疗方法无法取得令人满意的效果。眶周皮肤老化可能受益于富血小板血浆（PRP）注射。然而，关于PRP治疗眶周皮肤光老化的安全性和有效性的实验证据很少。为了研究PRP注射治疗眶周皮肤光老化的安全性和有效性，对20例患者的眶周皮肤注射PRP，并在治疗后的第一个月（M1）、第二个月（M2）和第三个月（M3）评估患者满意度。两名经验丰富的皮肤科医生根据国际公认的指南对患者治疗前后的皮肤进行独立评估。测量了皮肤水合作用、黑色素指数、红斑指数、皮肤亮度、经表皮水分流失（TEWL）、皮肤弹性和皮肤厚度等客观指标。一些主观指标，包括眼周色素沉着、眶下皱纹和静态鱼尾纹，有显著改善。一些客观指标，包括皮肤亮度、皮肤厚度和胶原蛋白强度，也有显著改善。眼袋和TEWL略有改善，但差异无统计学意义。患者对治疗的总体满意度较高，未观察到严重并发症，恢复情况良好。PRP注射治疗眶周皮肤光老化安全有效。
