Labarre Audrey, Guitard Ericka, Tossing Gilles, Parker J Alex
Centre de recherche du centre hospitalier de l'Université de Montréal (CRCHUM).
Neurosciences, Université de Montréal, Montréal, Quebec, Canada.
MicroPubl Biol. 2025 May 15;2025. doi: 10.17912/micropub.biology.001598. eCollection 2025.
Mutations in are linked to a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal dementia (ALS-FTD). The orthologue of is and we investigated whether mutants could be used for therapeutic discovery in ALS-FTD. Our results show that the small molecule pioglitazone and the probiotic HA-114 can alleviate mutant phenotypes. These findings suggest that mutants are suitable for modifier screens and could be adapted for high-throughput drug screening and microbiome studies to aid in discovering therapies for ALS-FTD.
[某种基因]的突变与多种神经退行性疾病相关，包括肌萎缩侧索硬化症和额颞叶痴呆（ALS-FTD）。[某种基因]的直系同源基因是[另一种基因]，我们研究了[另一种基因]突变体是否可用于ALS-FTD的治疗发现。我们的结果表明，小分子吡格列酮和益生菌HA-114可以减轻[另一种基因]突变体表型。这些发现表明，[另一种基因]突变体适用于修饰因子筛选，并且可用于高通量药物筛选和微生物组研究，以帮助发现ALS-FTD的治疗方法。
