Wen Jianting, Liu Jian, Wan Lei, Wang Fanfan
Department of Rheumatology and Immunology, First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui, China.
Institute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, Anhui, China.
Front Immunol. 2025 May 16;16:1557402. doi: 10.3389/fimmu.2025.1557402. eCollection 2025.
Rheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. Due to the lack of effective therapies, there is an urgent need for a deeper understanding of the etiopathogenesis of rheumatic diseases. In this review, we systematically summarized the role of cellular senescence in rheumatic diseases. We first focused on the mechanisms and hallmarks of cellular senescence, and then summarized evidence that can induce or aggravate cellular senescence, as well as related signaling pathways. Next, we discussed the mechanisms of interaction between cellular senescence and rheumatic diseases. Additionally, we focused on and elucidated the mechanisms and impacts of chondrocyte senescence and mesenchymal stem cell (MSC) senescence in osteoarthritis (OA) and systemic lupus erythematosus (SLE), respectively. Finally, we highlighted the potential of therapies targeting senescent cells in rheumatic diseases as a strategy, especially the multi-target effect of traditional Chinese medicine.
风湿性疾病是一种慢性炎症性疾病，给社会和经济带来了沉重负担。越来越多的证据表明，细胞衰老在炎症诱导的风湿性疾病中起重要作用。由于缺乏有效的治疗方法，迫切需要更深入地了解风湿性疾病的病因发病机制。在本综述中，我们系统总结了细胞衰老在风湿性疾病中的作用。我们首先关注细胞衰老的机制和特征，然后总结可诱导或加重细胞衰老的证据以及相关信号通路。接下来，我们讨论了细胞衰老与风湿性疾病之间的相互作用机制。此外，我们分别重点阐述了骨关节炎（OA）和系统性红斑狼疮（SLE）中软骨细胞衰老和间充质干细胞（MSC）衰老的机制及影响。最后，我们强调了针对风湿性疾病中衰老细胞的治疗策略的潜力，尤其是中药的多靶点作用。
