Xie Jinwei, Lu Lingyun, Yu Xijie
Department of Orthopaedics, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P.R.China.
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2021 Apr 15;35(4):519-526. doi: 10.7507/1002-1892.202011065.
To review the pathological effects of cellular senescence in the occurrence and development of osteoarthritis (OA) and potential therapeutic targets.
The role of chondrocyte senescence, synovial cell senescence, mesenchymal stem cells senescence in OA, and the biological mechanism and progress of chondrocyte senescence were summarized by consulting relevant domestic and abroad literature.
The existing evidence has basically made clear that chondrocyte senescence, mesenchymal stem cells senescence, and cartilage repair abnormalities, and the occurrence and development of OA have a certain causal relationship, and the role of the senescence of synovial cells, especially synovial macrophages in OA is still unclear. Transcription factors and epigenetics are the main mechanisms that regulate the upstream pathways of cellular senescence. Signal communication between cells can promote the appearance of senescent phenotypes in healthy cells. Targeted elimination of senescent cells and promotion of mesenchymal stem cells rejuvenation can effectively delay the progress of OA.
Cellular senescence is an important biological phenomenon and potential therapeutic target in the occurrence and development of OA. In-depth study of its biological mechanism is helpful to the early prevention and treatment of OA.
综述细胞衰老在骨关节炎（OA）发生发展中的病理作用及潜在治疗靶点。
通过查阅国内外相关文献，总结软骨细胞衰老、滑膜细胞衰老、间充质干细胞衰老在OA中的作用，以及软骨细胞衰老的生物学机制和研究进展。
现有证据基本明确软骨细胞衰老、间充质干细胞衰老与软骨修复异常和OA的发生发展存在一定因果关系，而滑膜细胞尤其是滑膜巨噬细胞衰老在OA中的作用仍不明确。转录因子和表观遗传学是调节细胞衰老上游通路的主要机制。细胞间信号通讯可促使健康细胞出现衰老表型。靶向清除衰老细胞和促进间充质干细胞年轻化可有效延缓OA进展。
细胞衰老在OA发生发展中是一种重要的生物学现象和潜在治疗靶点。深入研究其生物学机制有助于OA的早期防治。
