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三唑基官能化氮杂环卡宾的金（I）和金（III）配合物

Gold(i) and gold(iii) complexes of triazolyl-functionalised NHCs.

作者信息

Al-Buthabhak Hawraa S, Al-Ameed Karrar, Yu Yu, Sobolev Alexandre N, Moggach Stephen A, Al-Salami Hani, Ferro Vito, Baker Murray V

机构信息

Department of Chemistry, Faculty of Science, University of Kufa P. O. Box 21 Najaf 54001 Iraq

Department of Engineering, University of Warith Al-Anbiyaa Karbala Iraq.

出版信息

RSC Adv. 2025 May 30;15(23):18123-18141. doi: 10.1039/d5ra02655e. eCollection 2025 May 29.

DOI:10.1039/d5ra02655e
PMID:40453112
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12124398/
Abstract

Novel triazolyl-functionalised imidazolium salts and their corresponding Au/Au complexes were synthesised and characterised by spectroscopic techniques and X-ray diffraction studies. The reaction of (mono and bis carbene) Au complexes with thionyl chloride gave Au complexes. These Au complexes are reduced to Au complexes by DMSO dissolution, and react with silver nitrate to afford chelating complexes, where the triazolyl N atoms bind to gold. The triazolyl-functionalised Au complexes showed potency against ovarian cancer cells (OVCAR-8 cells, IC < 15 μM).

摘要

合成了新型三唑基官能化咪唑鎓盐及其相应的金/金配合物，并通过光谱技术和X射线衍射研究对其进行了表征。（单卡宾和双卡宾）金配合物与亚硫酰氯反应生成金配合物。这些金配合物通过二甲基亚砜溶解还原为金配合物，并与硝酸银反应生成螯合配合物，其中三唑基氮原子与金结合。三唑基官能化的金配合物对卵巢癌细胞（OVCAR-8细胞，IC<15μM）显示出活性。

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2
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Pharmaceutics. 2023 Jan 31;15(2):466. doi: 10.3390/pharmaceutics15020466.
3
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Chem Sci. 2022 Jul 22;13(32):9351-9360. doi: 10.1039/d2sc01966c. eCollection 2022 Aug 17.
4
Photochemical - isomerization around the -N-N[double bond, length as m-dash] bond in heterocyclic imines.杂环亚胺中围绕 -N-N[双键，长度为中划线]键的光化学异构化。
RSC Adv. 2020 Feb 4;10(10):5540-5550. doi: 10.1039/c9ra10730d.
5
Recent progress in the development of organometallics for the treatment of cancer.金属有机化合物在癌症治疗方面的最新进展。
Curr Opin Chem Biol. 2020 Jun;56:28-34. doi: 10.1016/j.cbpa.2019.11.001. Epub 2019 Dec 5.
6
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