Moreno-Alcántar Guillermo, Picchetti Pierre, Casini Angela
Chair of Medicinal and Bioinorganic Chemistry, School of Natural Sciences, Department of Chemistry, Technical University of Munich (TUM), Lichtenbergstr. 4, 85748, Garching b. München, Germany.
Karlsruhe Institute of Technology (KIT), Institute of Nanotechnology, Hermann-von-Helmholtz-Platz 1, 76344, Eggenstein-Leopoldshafen, Germany.
Angew Chem Int Ed Engl. 2023 May 22;62(22):e202218000. doi: 10.1002/anie.202218000. Epub 2023 Mar 15.
The discovery of the medicinal properties of gold complexes has fuelled the design and synthesis of new anticancer metallodrugs, which have received special attention due to their unique modes of action. Current research in the development of gold compounds with therapeutic properties is predominantly focused on the molecular design of drug leads with superior pharmacological activities, e.g., by introducing targeting features. Moreover, intensive research aims at improving the physicochemical properties of gold compounds, such as chemical stability and solubility in the physiological environment. In this regard, the encapsulation of gold compounds in nanocarriers or their chemical grafting onto targeted delivery vectors could lead to new nanomedicines that eventually reach clinical applications. Herein, we provide an overview of the state-of-the-art progress of gold anticancer compounds, andmore importantly we thoroughly revise the development of nanoparticle-based delivery systems for gold chemotherapeutics.
金配合物药用特性的发现推动了新型抗癌金属药物的设计与合成，这些药物因其独特的作用方式而备受关注。目前在开发具有治疗特性的金化合物方面的研究主要集中在设计具有卓越药理活性的药物先导物的分子设计上，例如通过引入靶向特性。此外，深入研究旨在改善金化合物的物理化学性质，如化学稳定性和在生理环境中的溶解度。在这方面，将金化合物封装在纳米载体中或化学接枝到靶向递送载体上可能会产生最终应用于临床的新型纳米药物。在此，我们概述了金抗癌化合物的最新进展，更重要的是，我们全面回顾了基于纳米颗粒的金化疗药物递送系统的发展。
