Kulkarni Pushkaraj A, Joshi Anagha A, Subramaniasamy Gopishankar, Prajapati Manish, Bradoo Renuka A
Department of ENT, Lokmanya Tilak Municipal General Hospital, Sion, Mumbai, Maharashtra 400022, India.
Iran J Otorhinolaryngol. 2025;37(3):115-122.
In patients with unilateral vocal fold paralysis (UVFP), voice therapy (VT), injection laryngoplasty (IL), and medialization thyroplasty (MT) are reported to produce significant improvement in voice quality (VQ). However, their long-term outcomes have not been sufficiently evaluated. We assessed the improvement in VQ with VT, IL, and MT over 12 months.
This prospective observational study involved 95 adult patients with UVFP, categorized into three groups: VT (n=55), IL (n=36), and MT (n=4). The VQ was assessed with voice handicap index (VHI), maximum phonation time (MPT), phonatory gap (PG), and breathy voice quality (BVQ) on Day 1, 15, 30, 90, 180, and 360.
In the VT group, the decrease in PG, VHI score, and BVQ score was significant from Day 15, 30, and 30, respectively, while MPT increased significantly from Day 15 (p<0.05). In the MT group, similar changes were observed; however, these changes were significant from Day 1 (p<0.05). In both the groups, the lowest PG, VHI score, and BVQ score, and the highest MPT were attained on Day 360. In the IL group, PG, VHI score, and BVQ score decreased significantly, and MPT values increased significantly at every visit (p<0.05). However, PG, VHI score, and BVQ score started increasing and MPT started decreasing from Day 90, 15, 90, and 180, respectively.
All treatment modalities improved the VQ significantly, immediately with IL and MT, and gradually with VT. Moreover, the improvement was long-term with VT and MT, and of intermediate duration with IL.
据报道,对于单侧声带麻痹(UVFP)患者,嗓音治疗(VT)、注射喉成形术(IL)和甲状软骨内移术(MT)可显著改善嗓音质量(VQ)。然而,它们的长期疗效尚未得到充分评估。我们评估了VT、IL和MT在12个月内对VQ的改善情况。
这项前瞻性观察性研究纳入了95例成年UVFP患者,分为三组:VT组(n = 55)、IL组(n = 36)和MT组(n = 4)。在第1天、15天、30天、90天、180天和360天,采用嗓音障碍指数(VHI)、最长发声时间(MPT)、发声间隙(PG)和嗓音粗糙程度(BVQ)评估VQ。
在VT组中,PG、VHI评分和BVQ评分分别从第15天、30天和30天开始显著下降,而MPT从第15天开始显著增加(p < 0.05)。在MT组中,观察到类似变化;然而,这些变化从第1天开始就很显著(p < 0.05)。在两组中,PG、VHI评分和BVQ评分的最低值以及MPT的最高值均在第360天达到。在IL组中,每次随访时PG、VHI评分和BVQ评分均显著下降,MPT值显著增加(p < 0.05)。然而,PG、VHI评分和BVQ评分分别从第90天、15天和90天开始上升,MPT从第180天开始下降。
所有治疗方式均能显著改善VQ,IL和MT立即起效,VT逐渐起效。此外,VT和MT的改善是长期的,IL的改善是中期的。