Department of Otorhinolaryngology, Centro Hospitalar Universitário S. João, EPE, Porto, Portugal; Unit of Otorhinolaryngology-Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Department of Otorhinolaryngology, Rouen University Hospital, Rouen, Normandy, France.
J Voice. 2021 Nov;35(6):924-926. doi: 10.1016/j.jvoice.2020.02.021. Epub 2020 Apr 3.
Unilateral vocal fold paralysis (UVFP) often leads to significant morbidity that may include dysphonia, swallowing problems and aspiration. The best timing for medialization procedures is still controversial. Published data suggest that early intracordal injection positively affects long-term outcomes.
To critically review current literature in order to determine if early treatment of acute UVFP influences clinical outcomes of the patients.
Nonsystematic literature review.
A literature review was performed, using the Pubmed database. All relevant articles published in English addressing the effect of early treatment in acute unilateral focal fold paralysis were analyzed. Twenty-six articles were included due to their scientific interest.
Published literature suggests that early intracordal injection in patients with UVFP reduces pulmonary infections, hospital length of stay and improves voice parameters. Also, patients who receive early intracordal injection seem to be less likely to undergo subsequent medialization thyroplasty.
Early intracordal injection should be offered to patients with newly diagnosed UVFP since it promotes a satisfactory position of the vocal fold and seems to improve clinical outcomes. More investigation, with long-term follow up data and treatment randomization, is necessary to develop clinical consensus for these patients.
单侧声带麻痹（UVFP）常导致显著的发病率，可能包括发音困难、吞咽问题和吸入。进行声带内移术的最佳时机仍存在争议。已发表的数据表明，早期声带内注射可对长期结果产生积极影响。
批判性地回顾现有文献，以确定急性单侧声带麻痹的早期治疗是否会影响患者的临床结果。
非系统性文献综述。
使用 Pubmed 数据库进行文献回顾。分析了所有发表的以探讨早期治疗对急性单侧局限性声带麻痹影响的英文相关文章。由于其科学意义，共纳入了 26 篇文章。
已发表的文献表明，急性单侧声带麻痹患者的声带内早期注射可减少肺部感染、住院时间并改善嗓音参数。此外，接受早期声带内注射的患者似乎不太可能随后接受声带内移术。
对于新诊断的单侧声带麻痹患者，应提供早期声带内注射治疗，因为它可促进声带满意的位置，并似乎改善临床结果。为这些患者制定临床共识需要进一步的研究，包括长期随访数据和治疗随机化。
