Audiology and Phoniatric Clinic, World Hearing Centre, Institute of Physiology and Pathology of Hearing, Warsaw, Kajetany, Poland.
Audiology and Phoniatric Clinic, World Hearing Centre, Institute of Physiology and Pathology of Hearing, Warsaw, Kajetany, Poland.
Am J Otolaryngol. 2022 Jan-Feb;43(1):103207. doi: 10.1016/j.amjoto.2021.103207. Epub 2021 Sep 10.
The objective was to evaluate the long-term voice outcomes in pa-tients with unilateral vocal fold paralysis treated with injection laryngoplasty using either cal-cium hydroxylapatite (CaHA) or hyaluronic acid (HA).
A single-centre retrospective study was performed. There were 75 patients with dysphonia due to unilateral vocal fold paralysis: injected with CaHA or injected with HA. We analysed Voice Handicap Index-30 (VHI), videostroboscopic images, auditory-perceptual (GRBAS), and acoustic measures (MDVP) in 6, 12, and 24 months after augmentation.
The mean change in VHI 24 months after augmentation was 29.14 in the CaHA group, and 22.88 in the HA group. There was an improvement of glottal gap 6, 12, and 24 months after augmentation in both groups. The GRBAS parameters were similar in both groups throughout the whole period. The MDVP pa-rameters decreased 6 and 12 months after augmentation and were similar in both groups. There were 4 patients augmented with CaHA (12.5%) who needed reintervention within 2 years of surgery and another 4 (9.3%) augmented with HA.
This study demonstrates that there are no long-term differences in voice outcomes or number of reaugmentations for injection laryn-goplasty with CaHA compared to HA.
评估单侧声带麻痹患者采用注射式喉成形术，分别使用羟基磷灰石（CaHA）和透明质酸（HA）治疗的长期嗓音效果。
进行了一项单中心回顾性研究。共有 75 名因单侧声带麻痹导致发声障碍的患者：接受 CaHA 注射或 HA 注射。我们在增强后 6、12 和 24 个月分析了嗓音障碍指数-30（VHI）、频闪喉镜图像、听觉感知（GRBAS）和声学测量（MDVP）。
增强后 24 个月时，CaHA 组的 VHI 平均变化为 29.14，HA 组为 22.88。两组在增强后 6、12 和 24 个月时都改善了声门裂。两组在整个研究期间的 GRBAS 参数均相似。MDVP 参数在增强后 6 和 12 个月下降，两组相似。有 4 名接受 CaHA 增强（12.5%）的患者在手术后 2 年内需要再次手术，另有 4 名接受 HA 增强（9.3%）的患者需要再次手术。
本研究表明，与 HA 相比，使用 CaHA 进行注射性喉成形术在长期嗓音效果或再次增强方面没有差异。
