Higuchi T, Uchide K, Honda K, Negoro H
J Endocrinol. 1985 Sep;106(3):311-6. doi: 10.1677/joe.0.1060311.
Developmental changes in levels of oxytocin in the blood and the pituitary gland and in oxytocin responses to oxytocin-releasing stimuli were investigated in the rat from the fetus close to term to the 40-day-old young adult. The oxytocin content of the pituitary gland rose gradually from fetuses of 21 days of gestation to 40-day-old rats. Pituitary oxytocin levels expressed in terms of body weight also increased up to day 25 after birth and declined slightly thereafter. In contrast, serum concentrations of oxytocin increased from day 21 of pregnancy up to day 5 after birth but were stable thereafter. Oxytocin levels in both blood and the pituitary gland were equal in 23-day-old fetuses and 1-day-old infants born on day 22 of pregnancy. There was no difference in serum and pituitary oxytocin levels in newborn pups and unborn littermates of day 22 or 23 of gestation. The i.p. injection of hypertonic saline induced a significant increase in serum oxytocin levels on day 5 and later, but no effect in the fetus on day 22 of gestation and in the 1-day-old infant. The responsiveness to the osmotic stimuli increased after 5 days of age. The i.p. injection of diethyldithiocarbamate, a noradrenaline synthesis inhibitor, or phenobarbitone was effective in raising blood oxytocin levels only in rats older than 10 and 20 days of age respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
研究了从接近足月的胎儿到40日龄年轻成年大鼠血液和垂体中催产素水平的发育变化，以及催产素对催产素释放刺激的反应。垂体催产素含量从妊娠21天的胎儿到40日龄大鼠逐渐升高。以体重表示的垂体催产素水平在出生后第25天之前也有所增加，此后略有下降。相比之下，催产素的血清浓度从妊娠第21天到出生后第5天增加，但此后保持稳定。在妊娠第22天出生的23日龄胎儿和1日龄婴儿中，血液和垂体中的催产素水平相等。妊娠第22天或23天的新生幼崽和未出生的同窝幼崽的血清和垂体催产素水平没有差异。腹腔注射高渗盐水在第5天及以后可使血清催产素水平显著升高，但对妊娠第22天的胎儿和1日龄婴儿没有影响。5日龄后对渗透压刺激的反应性增加。腹腔注射去甲肾上腺素合成抑制剂二乙基二硫代氨基甲酸盐或苯巴比妥分别仅在10日龄和20日龄以上的大鼠中有效提高血液催产素水平。（摘要截短于250字）
