Kumaresan P, Subramanian M, Anandarangam P B, Kumaresan M
J Endocrinol Invest. 1979 Jan-Mar;2(1):65-70. doi: 10.1007/BF03349277.
Radioimmunoassayable plasma and pituitary oxytocin (ROT) was measured during pregnancy and parturition. The highest mean plasma ROT level was seen in maternal rats on day 20 of pregnancy followed by a non significant decrease on day 21 reaching the basal level just before delivery. Plasma ROT level declined continuously up to the time of delivery of the first pup and then gradually increased until the completion of parturition. The highest maternal mean pituitary ROT level was found on day 21 pregnancy. Just before delivery of the first pup, the mean pituitary ROT level significantly declined by 22%. Pituitary ROT level declined steadily during the delivery of the first five pups. This pattern of reduction was reversed and ROT levels increased between the delivery of the fifth pup and the completion of labor. The increase of maternal pituitary and plasma ROT levels during delivery of the pups suggest that maternal ROT may play a role in normal parturition. Fetal hypothalamic-pituitary ROT does not seem to play any part in parturition.
在怀孕和分娩期间测量了可进行放射免疫测定的血浆和垂体催产素（ROT）。怀孕第20天的母鼠血浆ROT平均水平最高，随后在第21天出现不显著下降，在分娩前刚好达到基础水平。血浆ROT水平在第一只幼崽分娩前持续下降，然后逐渐上升直至分娩结束。怀孕第21天母鼠垂体ROT平均水平最高。在第一只幼崽分娩前，垂体ROT平均水平显著下降了22%。在分娩前五只幼崽期间，垂体ROT水平稳步下降。这种下降模式在第五只幼崽分娩至分娩结束期间发生逆转，ROT水平升高。幼崽分娩期间母鼠垂体和血浆ROT水平的升高表明，母鼠ROT可能在正常分娩中发挥作用。胎儿下丘脑 - 垂体ROT似乎在分娩中不起任何作用。
