用于质子超高剂量率类器官辐照的经济高效多样本缺氧室的开发与验证
Development and validation of cost-effective multi-sample hypoxia chambers for proton ultra-high dose rate organoid irradiations.
作者信息
de Koster Rutger Jan Cornelis, Gunawan Jeremy Putra, Peters Hans, Bussink Johan, Barazzuol Lara, van Goethem Marc-Jan, Gerbershagen Alexander, Coppes Robert Paul, Both Stefan
机构信息
Particle Therapy Research Center (PARTREC), University Medical Center Groningen, University of Groningen, The Netherlands.
Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands.
出版信息
Clin Transl Radiat Oncol. 2025 May 1;53:100970. doi: 10.1016/j.ctro.2025.100970. eCollection 2025 Jul.
The tissue sparing of ultra-high dose rate irradiation has been partially observed while controlling oxygen levels. Here, we developed a hypoxia system for high-throughput irradiations that accommodates embedded 3D cultures, such as organoids and spheroids, enabling the study of the effect of oxygen on radiation responses.
在控制氧水平的同时，已部分观察到超高剂量率辐射的组织 sparing 效应。在此，我们开发了一种用于高通量辐照的缺氧系统，该系统适用于嵌入的 3D 培养物，如类器官和球体，从而能够研究氧对辐射反应的影响。
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