Buiatti E, Geddes M, Kriebel D, Santucci M, Biggeri A
J Epidemiol Community Health. 1985 Sep;39(3):251-5. doi: 10.1136/jech.39.3.251.
Risk of lung cancer related to region of birth in Italy was investigated among migrants to Florence, in a case control study of all histologically confirmed incident cases of primary lung cancer in a three year period in that city (n = 376). Controls (n = 892) were patients in the same hospital of similar age, sex, date of admission, and smoking status with discharge diagnoses other than lung cancer or suicide. Information on place of birth and year of migration to Florence was collected directly from each subject, along with a detailed occupational history. Logistic regression models were used to calculate the odds ratio for birth in the south of Italy relative to birth elsewhere. Male migrants from the south have an odds ratio of lung cancer of 0.5 (95% limits 0.3 to 0.7) relative to those born elsewhere. This "protective effect" is not explained by smoking or by any known occupational risk. The risk is lowest among those born on the island of Sicily (odds ratio 0.2 compared to those born in the centre-north).
在一项针对佛罗伦萨移民的病例对照研究中，对意大利出生地区与肺癌风险之间的关系进行了调查。该研究涵盖了该城市三年内所有经组织学确诊的原发性肺癌新发病例（n = 376）。对照组（n = 892）为同一家医院中年龄、性别、入院日期和吸烟状况相似，但出院诊断不是肺癌或自杀的患者。直接从每个受试者那里收集了出生地点和移民到佛罗伦萨的年份信息，以及详细的职业史。使用逻辑回归模型计算意大利南部出生相对于其他地方出生的比值比。相对于在其他地方出生的男性移民，来自南部的男性患肺癌的比值比为0.5（95%置信区间为0.3至0.7）。这种“保护作用”无法用吸烟或任何已知的职业风险来解释。出生在西西里岛的人风险最低（与出生在中北部的人相比，比值比为0.2）。
