Buiatti E, Kriebel D, Geddes M, Santucci M, Pucci N
J Epidemiol Community Health. 1985 Sep;39(3):244-50. doi: 10.1136/jech.39.3.244.
A case control study of lung cancer in Florence, Italy was performed to investigate occupational risk factors for both men and women. The case series (n = 376) comprised all incident, histologically confirmed cases of primary lung cancer occurring in a three year period. Controls (n = 892) were patients in the same hospital of similar age, sex, date of admission, and smoking status with discharge diagnoses other than lung cancer or suicide. A detailed occupational history was collected from each subject directly. Logistic regression models were used to calculate odds ratios for specific occupations compared to all others. Among men, the lung cancer risk for bricklayers using firebrick and other refractory materials was elevated (adjusted odds ratio 6.5, 95% limits 2.1 and 20.9). Female hat makers, probably exposed to arsenic while making felt hats, had an elevated risk of lung cancer (6 cases versus 0 controls, p = 0.01). Risks in other occupations are discussed.
在意大利佛罗伦萨进行了一项肺癌病例对照研究，以调查男性和女性的职业风险因素。病例组（n = 376）包括在三年期间发生的所有新发病例、经组织学确诊的原发性肺癌病例。对照组（n = 892）是同一家医院中年龄、性别、入院日期和吸烟状况相似，但出院诊断不是肺癌或自杀的患者。直接从每个受试者收集详细的职业史。使用逻辑回归模型计算特定职业与所有其他职业相比的比值比。在男性中，使用耐火砖和其他耐火材料的砖匠患肺癌的风险升高（调整后的比值比为6.5，95%置信区间为2.1和20.9）。女性帽商在制作毡帽时可能接触到砷，患肺癌的风险升高（6例病例对0例对照，p = 0.01）。讨论了其他职业的风险。
