Wang Manda, Yu Liang
School of Sport and Science, Beijing Sport University, Beijing, China.
School of Strength and Conditioning Training, Beijing Sport University, Beijing, China.
Front Nutr. 2025 May 16;12:1585922. doi: 10.3389/fnut.2025.1585922. eCollection 2025.
Urolithin A (UA), a gut microbiota-derived metabolite of ellagic acid and ellagitannins, is emerging as a novel sports nutrition supplement with multifaceted benefits. UA demonstrates osteoprotective effects through dual regulation of bone remodeling, delays joint degeneration by reducing synovial inflammation, and enhances muscle endurance and peak oxygen uptake. Mechanistically, UA enhances mitochondrial -oxidation and potentially activating skeletal muscle adenosine 5'-monophosphate-activated protein kinase (AMPK) signaling and upregulating mitochondrial respiratory chain complex activity to exert ergogenic effects. Notably, the benefits of UA seem to be unaffected by diet. We propose once-daily dosing with tentative pre-exercise timing, though exercise's impact on UA pharmacokinetics requires further investigation. While UA's multifunctionality bridges gaps in conventional sports supplements, human trials validating ergogenic claims-particularly regarding muscle-specific adaptations and metabolic system modulation-remain critical. This synthesis positions UA as a promising yet incompletely characterized candidate in sports nutrition, warranting rigorous translational research.
尿石素A（UA）是一种由肠道微生物群产生的鞣花酸和鞣花单宁代谢产物，正作为一种具有多方面益处的新型运动营养补充剂而崭露头角。UA通过对骨重塑的双重调节发挥骨保护作用，通过减轻滑膜炎症延缓关节退变，并提高肌肉耐力和峰值摄氧量。从机制上讲，UA增强线粒体β-氧化，并可能激活骨骼肌5'-单磷酸腺苷激活蛋白激酶（AMPK）信号通路，上调线粒体呼吸链复合物活性，从而发挥促运动效果。值得注意的是，UA的益处似乎不受饮食影响。我们建议每日一次给药，并暂定在运动前服用，不过运动对UA药代动力学的影响还需要进一步研究。虽然UA的多功能性弥补了传统运动补充剂的不足，但验证促运动效果的人体试验——尤其是关于肌肉特异性适应和代谢系统调节方面——仍然至关重要。这一综述将UA定位为运动营养领域一个有前景但特性尚未完全明确的候选物，需要进行严格的转化研究。
