Aijaz Ayesha, Elloso Margarita, Chen Yufei, Chogan Faraz, Challagundla Bhavishya, Rix Graham, Hota Supriya, Matveev Anna, Jeschke Marc G
Department of Surgery, McMaster University, Hamilton, ON, Canada.
Hamilton Health Sciences, Center for Burn Research, Hamilton, ON, Canada.
iScience. 2025 Apr 17;28(5):112471. doi: 10.1016/j.isci.2025.112471. eCollection 2025 May 16.
Early initiation of wound regeneration and healing is the primary determinant of survival for burn patients. While superficial burns do not require secondary interventions and undergo spontaneous healing, full-thickness burns exceed the intrinsic capacity of body to induce skin regeneration. Herein, we developed a wound matrix system, referred to as PEGScarX that provides critical bioactive and bio-instructive cues to modulate cell fate decisions for burn wound healing. Our results indicate that PEGScarX promotes faster wound healing kinetics and reduces scar formation in burn wounds. PEGScarX induces fibroblast and epidermal stem cell repopulation, inhibits transdifferentiation of fibroblasts to myofibroblasts, and induces a pro-regenerative immune cell niche. These findings unravel an opportunity to reduce morbidity and mortality in burn patients due to inadequate wound regeneration and reduce the occurrence of pathological scaring.
伤口再生和愈合的早期启动是烧伤患者存活的主要决定因素。浅度烧伤不需要二次干预，可自行愈合，而深度烧伤则超出了身体诱导皮肤再生的内在能力。在此，我们开发了一种伤口基质系统，称为PEGScarX，它提供关键的生物活性和生物指导线索，以调节烧伤伤口愈合的细胞命运决定。我们的结果表明，PEGScarX促进烧伤伤口更快的愈合动力学并减少瘢痕形成。PEGScarX诱导成纤维细胞和表皮干细胞重新聚集，抑制成纤维细胞向肌成纤维细胞的转分化，并诱导促再生免疫细胞生态位。这些发现为减少因伤口再生不足导致的烧伤患者发病率和死亡率以及减少病理性瘢痕的发生提供了机会。
