Liu Xiaowei, Yu Haojie, Wang Li, Liang Ruixue, Xiang Yanxin, Song Xiaohang, Yang Ying, Huang Zhikun, Yang Jian, Shen Di, Sheng Yan
State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310058, P. R. China.
Center for Healthcare Materials, Shaoxing Institute, Zhejiang University, Shaoxing 312099, P. R. China.
J Mater Chem B. 2025 Jun 25;13(25):7502-7515. doi: 10.1039/d5tb00084j.
Hydrogels have extensive application in sutureless wound closure and healing. For relying on the natural recovery rate of the skin or tissue often results in prolonged healing periods due to the gradual process of wound contraction facilitated by cell migration, our approach involves the integration of two distinct layers to create a cohesive and innovative body-temperature responsive hydrogel tape (TRAT). The shape memory layer of P(PTHF--PEG--PETMP) possesses excellent mechanical properties and adjustable temperature-responsive characteristics. Upon integration with the adhesive layer consisting of a silk fibroin semi-interpenetrating network and poly(acrylic acid) covalent network, the resulting TRAT composite maintains remarkable body temperature responsive shape memory attributes while retaining robust wet surface adhesion capabilities (∼150 kPa). In virtue of its exceptional temperature-responsive and wet-adhesion features, TRAT can achieve varying degrees of wound contraction. It spontaneously unfolds from an initial folded state and securely attaches to the inner esophageal surface upon temperature stimulation. This holds promising implications for the development of anti-migration trachea stents, showing TRAT's potential in this application.
水凝胶在无缝合伤口闭合与愈合方面有广泛应用。由于依靠皮肤或组织的自然恢复率往往会因细胞迁移促进伤口收缩的渐进过程而导致愈合期延长，我们的方法是整合两个不同的层来制造一种有凝聚力且创新的体温响应水凝胶胶带（TRAT）。聚（聚四氢呋喃 - 聚乙二醇 - 三羟甲基丙烷三甲基丙烯酸酯）的形状记忆层具有出色的机械性能和可调节的温度响应特性。与由丝素蛋白半互穿网络和聚丙烯酸共价网络组成的粘合剂层整合后，所得的TRAT复合材料在保持强大的湿表面粘附能力（约150千帕）的同时，还保持着显著的体温响应形状记忆属性。凭借其特殊的温度响应和湿粘附特性，TRAT能够实现不同程度的伤口收缩。它从初始折叠状态自发展开，并在温度刺激下牢固地附着在内食管表面。这对抗迁移气管支架的开发具有重要意义，显示出TRAT在该应用中的潜力。
