Dubbelboer Ilse R, Olsén Lena, Pelander Lena, Lacroix Marlene Z, Claustre Lucie, Roques Beatrice, Ekstrand Carl
Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden.
J Vet Pharmacol Ther. 2025 Sep;48(5):380-388. doi: 10.1111/jvp.70003. Epub 2025 Jun 2.
The pharmacokinetics and plasma protein binding of amoxicillin in cats has not been thoroughly investigated. In a single-group sequential designed experimental study, amoxicillin was administered to six healthy cats intravenously, orally, and subcutaneously. Repeated blood samples were drawn after each administration, and amoxicillin concentrations were determined using High Performance Liquid Chromatography coupled to Triple Quadrupole Mass Spectrometry. Plasma amoxicillin data were subjected to population pharmacokinetic analysis, and pharmacokinetic parameters were estimated. The population clearance was 0.18 L/h∙kg, the volume of the central compartment was 0.12 L/kg, the highly perfused compartment was 0.009 L/kg, and the poorly perfused compartment was 0.002 L/kg. The bioavailability was 33% and 69% after oral and subcutaneous administration, respectively. After subcutaneous administration of a slow-release formulation, there was absorption rate-limited pharmacokinetics. The plasma protein binding was 0%-24%. The results increase the understanding of the amoxicillin pharmacokinetics in cats. Further studies combining the results with pharmacodynamic data and in silico simulations are warranted.
阿莫西林在猫体内的药代动力学和血浆蛋白结合情况尚未得到充分研究。在一项单组序贯设计的实验研究中，对六只健康猫分别进行了静脉注射、口服和皮下注射阿莫西林。每次给药后采集重复血样，并使用高效液相色谱-三重四极杆质谱联用仪测定阿莫西林浓度。对血浆阿莫西林数据进行群体药代动力学分析，并估算药代动力学参数。群体清除率为0.18 L/h∙kg，中央室容积为0.12 L/kg，高灌注室为0.009 L/kg，低灌注室为0.002 L/kg。口服和皮下给药后的生物利用度分别为33%和69%。皮下注射缓释制剂后，存在吸收速率限制的药代动力学。血浆蛋白结合率为0%-24%。这些结果增进了对阿莫西林在猫体内药代动力学的理解。有必要进一步将这些结果与药效学数据和计算机模拟相结合进行研究。
