海恩酮诱变机制：在黑腹果蝇中诱导温度敏感突变。

Mechanism of hycanthone mutagenesis: the induction of temperature-sensitive mutations in Drosophila melanogaster.

作者信息

Kramers P G

出版信息

Mutat Res. 1977 Mar;42(3):349-56. doi: 10.1016/s0027-5107(77)80039-0.

Abstract

A total of 358 sex-linked recessive lethals induced by hycanthone methane sulphonate (HMS) were checked for temperature sensitivity, along with 239 EMS-induced lethals as a positive control. Only about 1-2% of the HMS-induced lethals were temperature-sensitive, in contrast to about 7-8% for EMS-induced lethals. This can be reasonably explained by assuming that in Drosophila, HMS mainly acts by inducing frame-shift mutations or deletions.

摘要

检测了总共358个由甲磺酸海恩酮（HMS）诱导的性连锁隐性致死突变，并将239个由EMS诱导的致死突变作为阳性对照检测其温度敏感性。与EMS诱导的致死突变约7%-8%的温度敏感性相比，HMS诱导的致死突变中只有约1%-2%是温度敏感的。这可以通过假设在果蝇中，HMS主要通过诱导移码突变或缺失来起作用而得到合理的解释。