Low mutagenic activity of four hycanthone analogues in Drosophila melanogaster.
作者信息
Kramers P G, Knaap A G
出版信息
Mutat Res. 1975 Dec;31(6):395-400. doi: 10.1016/0165-1161(75)90049-7.
PMID:815810
Abstract
Four structural analogues of the antischistosomal drug hycanthone, indicated as IA-3, IA-4, IA-5, and IA-6, were tested for their ability to induce sex-linked recessive lethal mutations in Drosophila melanogaster. The compounds were administered to adult male flies, by abdominal injection or by feeding. Although in some cases a slight enhancement of the mutation frequency was observed, the analogues tested are considerably less mutagenic in this system than hycanthone itself, the concentrations applied being approximately of equal molarity.
摘要
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