Internal iliac artery calcification score predicts cardiovascular disease and mortality following living-donor kidney transplantation.

BACKGROUND

Cardiovascular disease remains a significant cause of death in kidney transplant recipients. While several studies have demonstrated the association of aortoiliac calcification with cardiovascular disease and mortality, few have reported the association between segmental (especially internal iliac artery) aortoiliac calcification and prognosis. This study evaluated the association between segmental aortoiliac calcification scores and cardiovascular disease incidence and mortality after kidney transplantation.

METHODS

This retrospective study included 104 primary living-donor kidney transplant recipients at our hospital between 2009 and 2023 who underwent preoperative computed tomography. The aortoiliac calcification quantification was performed on non-contrast computed tomography using the Agatston score. The aortoiliac artery was divided into four segments: distal aorta, common iliac artery, external iliac artery, and internal iliac artery.

RESULTS

The median follow-up period was 61 months; 15 recipients died, and 28 experienced cardiovascular disease. The ability to distinguish cardiovascular disease was the best for the internal iliac artery, followed by the common iliac artery (area under the curve: 0.75 and 0.73, respectively). The high calcification group, classified by the internal iliac artery and common iliac artery calcification scores, was associated with a poorer prognosis for cardiovascular disease-free and patient survival. Multivariate analysis revealed that internal iliac artery calcification and age were independent risk factors for cardiovascular disease (hazard ratio: 5.08 and 5.74, respectively) and patient survival (hazard ratio: 4.67 and 7.61, respectively).

CONCLUSION

The internal iliac artery calcification score was more closely associated with cardiovascular disease onset and mortality than other segment calcification scores.