Asnaashari Solmaz, Amjad Elham, Sokouti Babak
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Naunyn Schmiedebergs Arch Pharmacol. 2025 Jun 2. doi: 10.1007/s00210-025-04312-7.
Although doxorubicin (DOX) chemotherapy is widely used to treat malignant tumors, its cardiotoxicity restricts its widespread use. Flavonoids may mitigate DOX-induced cardiotoxicity. A systematic review was conducted to determine whether flavonoids can prevent DOX-induced cardiotoxicity. Therefore, it would be interesting to examine the effects of flavonoids on DOX activity. Based on a Boolean query in the well-known Scopus database, we present our review of doxorubicin and flavonoids simultaneously as combination drugs for cancer treatment. Following the retrieval and review of the intended investigations based on the input keywords, the anticancer mechanisms of flavonoids and doxorubicin are discussed, along with their effects on different targets. Several apoptotic/pro-apoptotic proteins are induced through targeted signaling pathways, which may activate several caspases that cause apoptosis, leading to cell death. In this study, flavonoids differentially modulated the efficacy of doxorubicin chemotherapeutics by interfering with chemotherapy-induced apoptosis and cell cycle arrest. Based on this information, we were able to better understand how dietary agents may affect chemotherapy.
尽管阿霉素（DOX）化疗被广泛用于治疗恶性肿瘤，但其心脏毒性限制了其广泛应用。类黄酮可能减轻阿霉素诱导的心脏毒性。进行了一项系统综述，以确定类黄酮是否能预防阿霉素诱导的心脏毒性。因此，研究类黄酮对阿霉素活性的影响将是很有意思的。基于著名的Scopus数据库中的布尔查询，我们展示了我们对阿霉素和类黄酮作为癌症治疗联合药物的综述。根据输入关键词检索和审查预期的研究后，讨论了类黄酮和阿霉素的抗癌机制，以及它们对不同靶点的影响。通过靶向信号通路诱导了几种凋亡/促凋亡蛋白，这可能激活几种导致凋亡的半胱天冬酶，从而导致细胞死亡。在本研究中，类黄酮通过干扰化疗诱导的凋亡和细胞周期停滞，差异性地调节了阿霉素化疗药物的疗效。基于这些信息，我们能够更好地理解膳食剂如何影响化疗。
