Asnaashari Solmaz, Amjad Elham, Sokouti Babak
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Cancer Cell Int. 2023 Sep 24;23(1):211. doi: 10.1186/s12935-023-03052-z.
Paclitaxel is a natural anticancer compound with minimal toxicity, the capacity to stabilize microtubules, and high efficiency that has remained the standard of treatment alongside platinum-based therapy as a remedy for a variety of different malignancies. In contrast, polyphenols such as flavonoids are also efficient antioxidant and anti-inflammatory and have now been shown to possess potent anticancer properties. Therefore, the synergistic effects of paclitaxel and flavonoids against cancer will be of interest. In this review, we use a Boolean query to comprehensively search the well-known Scopus database for literature research taking the advantage of paclitaxel and flavonoids simultaneously while treating various types of cancer. After retrieving and reviewing the intended investigations based on the input keywords, the anticancer mechanisms of flavonoids and paclitaxel and their synergistic effects on different targets raging from cell lines to animal models are discussed in terms of the corresponding involved signaling transduction. Most studies demonstrated that these signaling pathways will induce apoptotic / pro-apoptotic proteins, which in turn may activate several caspases leading to apoptosis. Finally, it can be concluded that the results of this review may be beneficial in serving as a theoretical foundation and reference for future studies of paclitaxel synthesis, anticancer processes, and clinical applications involving different clinical trials.
紫杉醇是一种天然抗癌化合物，毒性极小，具有稳定微管的能力，且效率高，一直是与铂类疗法并驾齐驱的多种不同恶性肿瘤治疗的标准方法。相比之下，类黄酮等多酚类物质也是高效的抗氧化剂和抗炎剂，现已证明具有强大的抗癌特性。因此，紫杉醇和类黄酮对癌症的协同作用将备受关注。在本综述中，我们利用布尔查询在著名的Scopus数据库中全面搜索文献，以研究在治疗各类癌症时同时利用紫杉醇和类黄酮的情况。在根据输入关键词检索和审查了预期的研究后，从相应涉及的信号转导方面讨论了类黄酮和紫杉醇的抗癌机制及其对从细胞系到动物模型等不同靶点的协同作用。大多数研究表明，这些信号通路会诱导凋亡/促凋亡蛋白，进而可能激活多种半胱天冬酶导致细胞凋亡。最后，可以得出结论，本综述的结果可能有助于为未来涉及不同临床试验的紫杉醇合成、抗癌过程和临床应用研究提供理论基础和参考。
