Ostojic Sergej M, Prémusz Viktória, Ács Pongrác
Faculty of Health Sciences, University of Pecs, Pecs, Hungary; Department of Nutrition and Public Health, University of Agder, Kristiansand, Norway.
Faculty of Health Sciences, University of Pecs, Pecs, Hungary.
Exp Gerontol. 2025 Aug;207:112798. doi: 10.1016/j.exger.2025.112798. Epub 2025 May 31.
Emerging evidence suggests that creatine, a naturally occurring amino acid derivative and conditionally essential nutrient, may modulate cellular senescence through mechanisms such as enhancing cellular energy homeostasis, mitigating oxidative stress, and influencing key signaling pathways implicated in aging processes. This review critically evaluates the current body of research, highlights existing gaps in the mechanistic understanding, and emphasizes the importance of targeted studies to further delineate creatine's role in cellular senescence and age-associated dysfunctions. By integrating perspectives from molecular biology, gerontology, and applied physiology, this paper aims to advance the understanding of creatine-based strategies as potential interventions for promoting healthy aging and preventing senescence-associated conditions.
新出现的证据表明，肌酸这种天然存在的氨基酸衍生物和条件必需营养素，可能通过增强细胞能量稳态、减轻氧化应激以及影响衰老过程中涉及的关键信号通路等机制来调节细胞衰老。本综述批判性地评估了当前的研究主体，突出了在机制理解方面存在的差距，并强调了针对性研究对于进一步阐明肌酸在细胞衰老和与年龄相关功能障碍中的作用的重要性。通过整合分子生物学、老年学和应用生理学的观点，本文旨在推进对基于肌酸的策略的理解，将其作为促进健康衰老和预防衰老相关病症的潜在干预措施。
