Yang Zhen, Zhang Pei-Pei, Xiong San-Chao, Lia Thongher
Department of Urology, Chengdu Second People's Hospital, Chengdu, 610011, People's Republic of China.
Department of Urology, The 926th Hospital of the People's Liberation Army, Kaiyuan, People's Republic of China.
BMC Urol. 2025 Jun 2;25(1):144. doi: 10.1186/s12894-025-01832-5.
Urethral hemangioma is an exceptionally rare benign vascular tumor, with scarce data available on its natural history and therapeutic strategies. The coexistence of carcinoma in situ within urethral hemangioma has not been previously documented in medical literature.
A 62-year-old woman presented with a protruding mass at the external urethral orifice. The lesion was completely excised by surgical resection. Histopathological analysis revealed squamous cell carcinoma in situ (SC-CIS) within the urethral hemangioma. The patient refused to undergo repeat surgical treatment again for SC-CIS due to surgical complications. The patient received adjuvant radiotherapy (total dose 50 Gy/25 fractions) following pathological confirmation of involved surgical margins. Long-term follow-up, including annual CT scans and cystoscopies, showed no evidence of disease recurrence at 7 years post-treatment.
Few cases of urethral hemangioma have been documented in the literature, and no previous reports have descried urethral hemangiomas coexisting with SC-CIS. Surgical treatment emphasizes the complete resection of the lesions. When margin involvement by malignant cells was identified, adjuvant radiotherapy is an essential component of the combined-modality approach. The 7-year recurrence-free survival in this case suggests that this combined-modality approach provides durable local control.
尿道血管瘤是一种极为罕见的良性血管肿瘤，关于其自然病史和治疗策略的数据稀缺。医学文献中此前尚无尿道血管瘤内原位癌共存的记录。
一名62岁女性因尿道外口有一突出肿物就诊。通过手术切除将病变完整切除。组织病理学分析显示尿道血管瘤内存在原位鳞状细胞癌（SC-CIS）。由于手术并发症，患者拒绝再次接受针对SC-CIS的重复手术治疗。在手术切缘病理证实受累后，患者接受了辅助放疗（总剂量50 Gy/25次分割）。包括每年CT扫描和膀胱镜检查在内的长期随访显示，治疗后7年无疾病复发迹象。
文献中记录的尿道血管瘤病例很少，此前也没有关于尿道血管瘤与SC-CIS共存的报道。手术治疗强调病变的完整切除。当发现恶性细胞累及切缘时，辅助放疗是综合治疗方法的重要组成部分。该病例7年无复发生存表明这种综合治疗方法能提供持久的局部控制。
