Kashani Amir H, Berendschot Tos T J M, Bonnin Sophie, Sobrin Lucia, De Jesus Danilo Andrade, Brea Luisa Sanchez, Martinez Ana Collazo, Raman Rajiv, de Vries Victor A, Huang Haifan, MacGillivray Tom, Ramdas Wishal D, van der Heide Frank C T
Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland, USA.
Department of Biomedical Engineering and Ophthalmology, Johns Hopkins Hospital, Baltimore, Maryland, USA.
Alzheimers Dement. 2025 Jun;21(6):e70252. doi: 10.1002/alz.70252.
Widespread use of retinal optical coherence tomography angiography (OCT-A) imaging requires methodological and analytical consensus to ensure reproducible and accurate results in epidemiological studies on Alzheimer's disease and related dementias (ADRD).
A consensus framework for assessment of fovea-centered 3 × 3-mm and 6 × 6-mm OCT-A image quality was developed, and reproducibility was reported. Agreement was assessed for overall image quality and image quality relevant for vessel density (VD) quantification and foveal avascular zone (FAZ) metrics. An analytic framework was also developed.
Intergrader agreements for overall 3 × 3 mm image quality and quantitative assessment of VD and FAZ ranged between 71% and 87% (52 images). Intragrader agreements ranged between 82% and 93% (n = 27 images). Intergrader agreements were similar for 6 × 6-mm images. Three analytic scenarios were developed to account for bias that may result from image quality and ocular comorbidities.
These recommendations provide a framework for working with OCT-A imaging in epidemiological studies on ADRD.
Multicentric consensus on quality criteria for use of optical coherence tomography angiography (OCT-A) images in population studies was achieved, considering commonly used protocols acquired with commercially available devices (Heidelberg, Zeiss, and Topcon). Considerable inter- and intrarater agreement was achieved for assessment of OCT-A image quality. A framework for harmonized data analyses was designed. Standardized analyses may accelerate the development of scalable retinal imaging biomarkers for ADRD.
视网膜光学相干断层扫描血管造影（OCT-A）成像的广泛应用需要方法学和分析方面的共识，以确保在阿尔茨海默病及相关痴呆症（ADRD）的流行病学研究中获得可重复且准确的结果。
制定了一个用于评估以黄斑中心凹为中心的3×3毫米和6×6毫米OCT-A图像质量的共识框架，并报告了其可重复性。对整体图像质量以及与血管密度（VD）定量和黄斑无血管区（FAZ）指标相关的图像质量进行了一致性评估。还开发了一个分析框架。
3×3毫米图像整体质量以及VD和FAZ定量评估的评分者间一致性在71%至87%之间（52张图像）。评分者内一致性在82%至93%之间（n = 27张图像）。6×6毫米图像的评分者间一致性相似。制定了三种分析方案，以解决可能因图像质量和眼部合并症导致的偏差。
这些建议为在ADRD流行病学研究中使用OCT-A成像提供了一个框架。
就人群研究中使用光学相干断层扫描血管造影（OCT-A）图像的质量标准达成了多中心共识，考虑了使用市售设备（海德堡、蔡司和拓普康）获取的常用方案。在评估OCT-A图像质量方面，评分者间和评分者内均达成了相当高的一致性。设计了一个统一数据分析的框架。标准化分析可能会加速用于ADRD的可扩展视网膜成像生物标志物的开发。
