Alifarsangi Atena, Esmaeili-Mahani Saeed, Salarkia Ehsan, Alizadeh Elham, Abbasnejad Mehdi
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, Iran.
Addict Health. 2025 Jan;17:1543. doi: 10.34172/ahj.1543. Epub 2025 Mar 16.
Morphine dependence is a significant concern because of its potential for inducing addiction and adverse withdrawal symptoms. Naringin, a flavonoid compound found in citrus fruits, has shown promise in various pharmacological activities, including analgesic and anti-inflammatory effects. However, its potential role in inhibiting or reducing morphine dependence has not been extensively investigated yet. This study aimed to determine whether naringin can inhibit or reduce physical morphine dependence in rats.
Morphine dependence was induced in rats through chronic injection of the drug for 7 days. Also, different doses of naringin (10, 25, and 50 mg/kg) were administered 15 minutes prior to morphine injection in three experimental groups. The effect of naringin pretreatment on drug withdrawal-associated symptoms, including body weight, jumping, abdominal contraction, grooming, ptosis, diarrhea, and teeth chattering, was evaluated.
The animals experiencing morphine dependence exhibited significant body weight loss. However, administration of naringin before morphine injection prevented this loss by 50%. Also, drug withdrawal symptoms such as jumping, abdominal contraction, grooming, diarrhea, and teeth chattering were significantly increased in the rats. Interestingly, the prescription of naringin significantly reduced these symptoms. Ptosis was observed in all rats receiving morphine, while naringin did not significantly affect this symptom. Furthermore, the inhibitory effect of naringin on morphine physical dependence was found to be dose-dependent.
Naringin pretreatment demonstrated potential in inhibiting or reducing physical morphine dependence in rats. These findings suggest that naringin may have therapeutic potential in managing morphine dependence and associated withdrawal symptoms.
由于吗啡具有成瘾性及不良戒断症状的潜在风险，吗啡依赖成为一个重要问题。柚皮苷是一种存在于柑橘类水果中的黄酮类化合物，在多种药理活性方面表现出前景，包括镇痛和抗炎作用。然而，其在抑制或减轻吗啡依赖方面的潜在作用尚未得到广泛研究。本研究旨在确定柚皮苷是否能抑制或减轻大鼠的身体吗啡依赖。
通过连续7天给大鼠注射吗啡诱导吗啡依赖。此外，在三个实验组中，在注射吗啡前15分钟给予不同剂量的柚皮苷（10、25和50毫克/千克）。评估柚皮苷预处理对与药物戒断相关症状的影响，包括体重、跳跃、腹部收缩、梳理毛发、眼睑下垂、腹泻和打颤。
出现吗啡依赖的动物体重显著减轻。然而，在注射吗啡前给予柚皮苷可使体重减轻减少50%。此外，大鼠的跳跃、腹部收缩、梳理毛发、腹泻和打颤等药物戒断症状显著增加。有趣的是，给予柚皮苷可显著减轻这些症状。所有接受吗啡的大鼠均出现眼睑下垂，而柚皮苷对该症状无显著影响。此外，发现柚皮苷对吗啡身体依赖的抑制作用呈剂量依赖性。
柚皮苷预处理显示出抑制或减轻大鼠身体吗啡依赖的潜力。这些发现表明，柚皮苷在治疗吗啡依赖及相关戒断症状方面可能具有治疗潜力。
