Horváth-Puhó Erzsébet, Pedersen Lars, Martiny Søren Korsgaard, Amdisen Lau, Viuff Jakob Hansen, Ekholm Ola, Sørensen Henrik Toft
Department of Clinical Epidemiology and Center for Population Medicine, Aarhus University and Aarhus University Hospital, Aarhus N, 8200, Denmark.
National Institute of Public Health, University of Southern Denmark, Copenhagen, 1455, Denmark.
Clin Epidemiol. 2025 May 29;17:485-495. doi: 10.2147/CLEP.S522468. eCollection 2025.
Venous thromboembolism (VTE) is a common disease with a serious prognosis. Nonetheless, many aspects of this multicausal disease are poorly understood. The aim of establishing was to study VTE risk and prognosis within a life-course context.
was based on respondents to the questionnaire-based Danish National Health Survey (DNHS) conducted in 2010, 2013, and 2017 and was linked to Danish national health and administrative registries.
A total of 474,022 unique respondents to the DNHS were included in this cohort, 8,460 of whom were diagnosed with VTE before the survey response date. The survey's response rate varied between 54% and 60%. The median age at the survey response date was 54 years (interquartile range: 40-66 years), and 46.1% of respondents were men. The cohort contains detailed information on lifestyle factors (smoking habits, alcohol consumption, physical activity level, and dietary habits), health status indicators (healthcare-seeking behavior, body mass index, self-rated health, and mental distress), and self-reported morbidities. In addition, the survey data were linked to records in Danish medical and administrative registries to obtain information on clinical data and outcomes, including hospitalizations, medication use, laboratory test results, labor market participation, vital status, and causes of death.
is a valuable data resource for use in future studies on VTE research, with a focus on risk factors, complications, interactions, and prognosis.
静脉血栓栓塞症（VTE）是一种常见疾病，预后严重。然而，这种多病因疾病的许多方面仍未得到充分了解。本研究的目的是在生命历程背景下研究VTE风险和预后。
本研究基于对2010年、2013年和2017年进行的基于问卷的丹麦国家健康调查（DNHS）的受访者，并与丹麦国家健康和行政登记处相链接。
本队列共纳入474,022名DNHS的独特受访者，其中8,460人在调查回复日期之前被诊断为VTE。调查的回复率在54%至60%之间。调查回复日期的中位年龄为54岁（四分位间距：40 - 66岁），46.1%的受访者为男性。该队列包含有关生活方式因素（吸烟习惯、饮酒、身体活动水平和饮食习惯）、健康状况指标（就医行为、体重指数、自评健康和心理困扰）以及自我报告疾病的详细信息。此外，调查数据与丹麦医疗和行政登记处的记录相链接，以获取有关临床数据和结果的信息，包括住院、用药、实验室检查结果、劳动力市场参与情况、生命状态和死亡原因。
本研究是未来VTE研究的宝贵数据资源，重点关注危险因素、并发症、相互作用和预后。
