Enger April, Dossett James, Clavell Christine, Eid Alen, Kuenstner William, Pumariega Nicole, Ghorayeb Ghassan
West Virginia University Eye Institute, West Virginia University, Morgantown, WV, USA.
Eye Associates of New Mexico, Albuquerque, NM, USA.
J Vitreoretin Dis. 2025 May 31:24741264251346825. doi: 10.1177/24741264251346825.
To present a series of cases of acute endophthalmitis after intravitreal (IVT) sustained-release dexamethasone implantation (Ozurdex) with an unusually delayed onset. A retrospective review was performed of 3 patients presenting to West Virginia University Eye Institute and diagnosed with acute endophthalmitis 16 days, 18 days, and 35 days after dexamethasone implantation. The presenting visual acuities (VAs) were counting fingers at face to hand motions (HM) only. Each patient had an aqueous or vitreous tap with injection of IVT antibiotics followed by pars plana vitrectomy. The dexamethasone implants were not removed. All cultures returned positive, including , and . The 3 patients' final VAs were 20/60, 20/100, and HM only, respectively. Delayed-onset acute endophthalmitis after dexamethasone implantation represents a clinical challenge, potentially occurring up to weeks after the injection. Sustained suspicion for endophthalmitis is warranted given that cases may present beyond what is typical for postinjection endophthalmitis.
呈现一系列玻璃体内（IVT）缓释地塞米松植入术（Ozurdex）后发生的急性眼内炎病例，其发病延迟异常。对3例就诊于西弗吉尼亚大学眼科学院并在植入地塞米松后16天、18天和35天被诊断为急性眼内炎的患者进行了回顾性研究。初始视力仅为面部数指至手动（HM）。每位患者均进行了房水或玻璃体穿刺并注射IVT抗生素，随后行玻璃体切割术。地塞米松植入物未取出。所有培养结果均为阳性，包括……。3例患者的最终视力分别为20/60、20/100和仅为HM。地塞米松植入后延迟发作的急性眼内炎是一项临床挑战，可能在注射后数周发生。鉴于病例可能在注射后眼内炎的典型表现期之后出现，持续怀疑眼内炎是必要的。
