衰弱与老年心力衰竭患者身体机能的关系。
Association between frailty and physical performance in older patients with heart failure.
机构信息
Department of Cardiology, Ajou University School of Medicine, Suwon-si, Republic of Korea.
Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
出版信息
Clin Cardiol. 2023 Dec;46(12):1530-1537. doi: 10.1002/clc.24142. Epub 2023 Sep 7.
BACKGROUND
Frailty is an issue in patients with heart failure (HF). A Korean version of the frailty scale (K-FRAIL) has been developed.
HYPOTHESIS
We aimed to analyze the relationship between the K-FRAIL scale and physical performance in patients with HF.
METHODS
This study included 142 patients with HF aged ≥65 years from a single center. Muscular fitness was assessed using the handgrip test and knee extensor strength measurement. Aerobic capacity was assessed using the cardiopulmonary exercise test and 6-min walk test (6MWT). Frailty was assessed using the K-FRAIL questionnaire.
RESULTS
Peak VO and 6MWT scores significantly decreased as frailty worsened, but handgrip and knee extensor strength did not. In the multivariate analysis, peak VO (β = -.31; p = .002) and 6MWT score (β = -.38; p < .001) showed significant inverse associations with the K-FRAIL score. Based on the receiver operating characteristic curve analysis, the cut-off values of peak VO (hazard ratio, 5.08; p = .023) and 6MWT (hazard ratio, 3.99; p = .020) were independent predictors of frailty.
CONCLUSION
In older patients with HF, physical performance correlates with the degree of frailty. The K-FRAIL scale is correlated with the peak VO and 6MWT.
背景
衰弱是心力衰竭（HF）患者的一个问题。已经开发出一种韩国衰弱量表（K-FRAIL）。
假说
我们旨在分析 K-FRAIL 量表与 HF 患者身体表现之间的关系。
方法
这项研究纳入了来自单一中心的 142 名年龄≥65 岁的 HF 患者。使用握力测试和膝关节伸肌力量测量评估肌肉力量。使用心肺运动测试和 6 分钟步行测试（6MWT）评估有氧能力。使用 K-FRAIL 问卷评估衰弱。
结果
随着衰弱的恶化，峰值 VO 和 6MWT 评分显著降低，但握力和膝关节伸肌力量没有。在多变量分析中，峰值 VO（β=-.31；p=.002）和 6MWT 评分（β=-.38；p<.001）与 K-FRAIL 评分呈显著负相关。基于受试者工作特征曲线分析，峰值 VO（危险比，5.08；p=.023）和 6MWT（危险比，3.99；p=.020）的截止值是衰弱的独立预测因子。
结论
在年龄较大的 HF 患者中，身体表现与衰弱程度相关。K-FRAIL 量表与峰值 VO 和 6MWT 相关。
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