Khan Sabir, Hou Bing, Khan Muhammad Nadeem, Shafiq Muhammad, Cai Lin, Fang Wenjie, Wang Qian, Bilal Hazrat, Zeng Yuebin
Department of Dermatology, The Second Affiliated Hospital of Shantou University Medical College, Shantou, China.
Department of Clinical Laboratory, Skin and Venereal Diseases Prevention and Control Hospital of Shantou City, Shantou, Guangdong, China.
Front Cell Infect Microbiol. 2025 May 19;15:1549470. doi: 10.3389/fcimb.2025.1549470. eCollection 2025.
A biomarker is an important indicator of a normal physiological or pathological process, or a pharmacological response to a therapeutic intervention. This retrospective study aimed to measure blood biomarkers in wound patients, identify the microorganisms responsible for wound infections and determine their drug susceptibility patterns at a tertiary care hospital in China. The study was conducted between 2022 and 2024, including 279 patients. A total of 33 microbial species were isolated using culture techniques, identified, and analyzed for their antibiotic susceptibility. The organisms were predominantly gram-positive (50.8%), with (80.2%) being the most prevalent species. Among the gram-negative bacteria (41.2%), (22.6%) was the most predominant species. Biomarkers such as white blood cells, neutrophils, lymphocytes, and erythrocyte sedimentation rate (ESR) values were higher than normal in most of microbial species associated with wound infections. The WBC value in gram-positive infections and the neutrophil and ESR values in fungal infections were statistically significantly higher than the normal range ( = 0.0002, = 0.002, and = 0.003, respectively). Albumin levels were high value in and (0.48 and 0.56 respectively), while lymphocytes levels were the lowest value (-0.62) in . Resistance to at least one antibiotic was identified in 82.4% of the isolates. The prevalence of multidrug-resistant microbes in different wound infections is a significant concern in China. A health awareness campaign, coupled with improved hygiene measures, should be implemented to prevent the spread of microorganisms responsible for wound infections within the community.
生物标志物是正常生理或病理过程的重要指标，或是对治疗干预的药理反应。这项回顾性研究旨在测定伤口患者的血液生物标志物，确定导致伤口感染的微生物，并在中国一家三级医院确定其药敏模式。该研究于2022年至2024年进行，包括279名患者。使用培养技术共分离出33种微生物，进行鉴定并分析其抗生素敏感性。这些微生物主要为革兰氏阳性菌（50.8%），其中（80.2%）是最常见的菌种。在革兰氏阴性菌中（41.2%），（22.6%）是最主要的菌种。与伤口感染相关的大多数微生物种类中，白细胞、中性粒细胞、淋巴细胞和红细胞沉降率（ESR）值等生物标志物高于正常水平。革兰氏阳性菌感染中的白细胞值以及真菌感染中的中性粒细胞和ESR值在统计学上显著高于正常范围（分别为 = 0.0002、 = 0.002和 = 0.003）。白蛋白水平在和中较高（分别为0.48和0.56），而淋巴细胞水平在中最低（-0.62）。82.4%的分离株对至少一种抗生素耐药。在中国，不同伤口感染中多重耐药微生物的流行是一个重大问题。应开展健康宣传活动，并加强卫生措施，以防止社区内导致伤口感染的微生物传播。
