Assistant Professor of Microbiology and Immunology, Microbiology and Immunology Department, Faculty of Pharmacy, Sohag University, 82524, Province, Sohag, Egypt.
Teaching assistant of Microbiology and Immunology, Microbiology and Immunology Department, Faculty of Pharmacy, Deraya University, Elminya, Egypt.
BMC Res Notes. 2023 Jun 19;16(1):106. doi: 10.1186/s13104-023-06379-y.
This cross-sectional survey aimed to identify aerobic bacteria, antimicrobial resistance, and multi-drug resistance profiles of bacteria isolated from different wound infections among a group of Egyptian patients.
Of 120 positive samples, 170 isolates were identified. Polymicrobial infections were determined in 55% of samples. The dominant Gram-positive isolated strains were Staphylococcus aureus, especially from wound infections because of accidents (71.8%). Piperacillin, methicillin, ampicillin/sulbactam, and amoxicillin/clavulanic acid were all highly resistant to S. aureus and Coagulase-negative Staphylococci. The prevalence of methicillin-resistant S. aureus in wound infections was 89.9%. S. aureus showed superior sensitivity to vancomycin (85.3%) and linezolid (81.3%). The highest prevalence of Gram-negative isolates was for Pseudomonas aeruginosa (40%), which was highly sensitive to ciprofloxacin (79.2%) and highly resistant to levofloxacin (83.3%). Several isolates revealed a multi-drug resistance profile (52.4%). The overall MDR rate of Gram-positive and Gram-negative isolates were 50% and 54.9%, respectively.
The prevalence of MRSA isolated from various wound infections and MDR is a warning issue in Upper Egypt. It should implement a health education strategy and hygiene measures to prevent the spread of wound infection-causing organisms in the community.
本横断面研究旨在鉴定一组埃及患者不同伤口感染中分离的需氧菌、抗菌药物耐药性和多药耐药菌谱。
在 120 份阳性样本中，鉴定出 170 株分离株。55%的样本存在混合感染。主要的革兰阳性分离株为金黄色葡萄球菌，尤其是因事故导致的伤口感染（71.8%）。哌拉西林、甲氧西林、氨苄西林/舒巴坦和阿莫西林/克拉维酸对金黄色葡萄球菌和凝固酶阴性葡萄球菌均高度耐药。伤口感染中耐甲氧西林金黄色葡萄球菌的流行率为 89.9%。金黄色葡萄球菌对万古霉素（85.3%）和利奈唑胺（81.3%）的敏感性较高。革兰氏阴性分离株中最常见的是铜绿假单胞菌（40%），对环丙沙星（79.2%）高度敏感，对左氧氟沙星（83.3%）高度耐药。几种分离株表现出多药耐药谱（52.4%）。革兰氏阳性和革兰氏阴性分离株的总 MDR 率分别为 50%和 54.9%。
从各种伤口感染中分离出的耐甲氧西林金黄色葡萄球菌和 MDR 的流行率是上埃及的一个警告问题。应实施健康教育策略和卫生措施，以防止社区中导致伤口感染的病原体传播。
