正畸力作用下牙周膜成纤维细胞的分化潜能

Differentiation potential of periodontal Col1 cells under orthodontic force.

作者信息

Wang Xinyu, Huang Xiangru, Gao Xin, Xu Hongyuan, Jin Anting, Wang Xijun, Sun Siyuan, Liu Yuanqi, Zhu Yanfei, Liu Jingyi, Lu Tingwei, Dai Qinggang, Jiang Lingyong

机构信息

Center of Craniofacial Orthodontics, Department of Oral and Cranio-maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, China.

The 2nd Dental Center, Ninth People's Hospital, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, China.

出版信息

Mechanobiol Med. 2023 Oct 29;2(1):100026. doi: 10.1016/j.mbm.2023.100026. eCollection 2024 Mar.

DOI:10.1016/j.mbm.2023.100026

PMID:40458548

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12128636/

Abstract

Mechanical force often has clear effects on tissue niche remodeling. However, the changes in stem cells and their roles in clinical treatment remain unclear. Orthodontic tooth movement (OTM), the primary approach to treating dental-maxillofacial malformations, involves reconstruction of periodontal tissue. Herein, lineage tracing revealed that Col1 cells are distributed in the periodontal ligament and are sensitive to mechanical forces during OTM. Immunofluorescence analysis confirms that Col1 cells can differentiate into osteoblasts and fibroblasts under orthodontic force. Moreover, Col1 cells may be involved in angiogenesis. These findings suggest that Col1 cells play a crucial role in the mechanical remodeling of periodontal tissue during OTM and may serve as a valuable tool for studying the mechanism of OTM.

摘要

机械力通常对组织微环境重塑有明显影响。然而，干细胞的变化及其在临床治疗中的作用仍不清楚。正畸牙齿移动（OTM）是治疗牙颌面畸形的主要方法，涉及牙周组织的重建。在此，谱系追踪显示Col1细胞分布于牙周韧带中，并且在正畸牙齿移动过程中对机械力敏感。免疫荧光分析证实，在正畸力作用下，Col1细胞可分化为成骨细胞和成纤维细胞。此外，Col1细胞可能参与血管生成。这些发现表明，Col1细胞在正畸牙齿移动过程中对牙周组织的机械重塑起关键作用，并且可能成为研究正畸牙齿移动机制的有价值工具。