Department of Biological Chemistry, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jonsson Comprehensive Cancer Center; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA 90095, USA.
Development. 2023 Oct 15;150(20). doi: 10.1242/dev.199961. Epub 2023 Jun 1.
Diet contributes to health at all stages of life, from embryonic development to old age. Nutrients, including vitamins, amino acids, lipids and sugars, have instructive roles in directing cell fate and function, maintaining stem cell populations, tissue homeostasis and alleviating the consequences of aging. This Review highlights recent findings that illuminate how common diets and specific nutrients impact cell fate decisions in healthy and disease contexts. We also draw attention to new models, technologies and resources that help to address outstanding questions in this emerging field and may lead to dietary approaches that promote healthy development and improve disease treatments.
饮食在生命的各个阶段都对健康起着重要作用，从胚胎发育到老年。营养素，包括维生素、氨基酸、脂质和糖，在指导细胞命运和功能、维持干细胞群体、组织内稳态和减轻衰老后果方面具有指导作用。这篇综述强调了最近的发现，这些发现阐明了常见饮食和特定营养素如何在健康和疾病环境中影响细胞命运决策。我们还提请注意新的模型、技术和资源，这些模型、技术和资源有助于解决这一新兴领域的悬而未决的问题，并可能导致促进健康发育和改善疾病治疗的饮食方法。
